ArticleArchives of virology2024
Isolation and characterization of Iwanai Valley virus, a new tick-borne nairovirus from Ixodes ovatus ticks in Hokkaido, Japan.
Article in Archives of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Metaviromic analysis of Ixodes ticks in Northwestern Russia reveals high viral diversity and novel RNA virus lineages.Scientific reports · 2026Article
- Pathogenicity of a novel orthonairovirus, Iwanai Valley virus, in mice.The Journal of veterinary medical science · 2026Article
- Structural Features of Nucleoproteins from the Recently DiscoveredInternational journal of molecular sciences · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Most members of the genus Orthonairovirus, represented by Crimean-Congo hemorrhagic fever virus and Nairobi sheep disease virus, are tick-borne, and some have become a public health concern in recent years. Here, we report the isolation and genetic and biological characterization of a new orthonairovirus, designated as "Iwanai Valley virus" (IWVV), from Ixodes ovatus ticks in Hokkaido, Japan. The amino acid sequence of the viral nucleoprotein (NP) was found to be 34-45% identical to those of known orthonairoviruses. Phylogenetic analysis based on amino acid sequences of the viral NP revealed that IWVV is closely related to human-pathogenic tick-borne orthonairoviruses, including Songling virus, Tacheng tick virus 1, and Yezo virus, which were recently discovered in East Asia. BHK-21 (Syrian hamster kidney), Vero (African green monkey kidney), SW-13 (human adrenal adenocarcinoma), HuH-7 (human hepatocellular carcinoma), and ISE6 (Ixodes scapularis tick embryo) cells were found to be susceptible to IWVV infection. Notably, several human-derived cell lines supported efficient replication of the virus. Our findings provide new insights into the diversity, evolutionary dynamics, and geographical distribution of orthonairoviruses in East Asia.
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Registered trials
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