Evidence map›Paper›PMID 39708111›Full record

ArticleWorld journal of urology2024

Impact of neurovascular bundle preservation on biochemical recurrence after robot-assisted radical prostatectomy for high-risk prostate cancer.

Hiroki Hagimoto, Masashi Kubota, Yoshiyuki Matsui, Takayuki Sumiyoshi, Ryoichi Saito, Takehiko Segawa, Shigeki Fukuzawa, Kenji Mitsumori, Toru Yoshida, Toshiya Akao and 9 more

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In one paragraph

Article in World journal of urology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Hiroki HagimotoDepartment of Urology and Retroperitoneal Surgery, National Cancer Center Hospital, Tokyo, Japan.
Masashi KubotaDepartment of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Yoshiyuki MatsuiDepartment of Urology and Retroperitoneal Surgery, National Cancer Center Hospital, Tokyo, Japan.
Takayuki SumiyoshiDepartment of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Ryoichi SaitoDepartment of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Takehiko SegawaDepartment of Urology, Kyoto City Hospital, Kyoto, Japan.
Shigeki FukuzawaDepartment of Urology, Shimada General Medical Center, Shizuoka, Japan.
Kenji MitsumoriDepartment of Urology, Osaka Red Cross Hospital, Osaka, Japan.
Toru YoshidaDepartment of Urology, Shiga General Hospital, Moriyama, Shiga, Japan.
Toshiya AkaoDepartment of Urology, Rakuwakai Otowa Hospital, Kyoto, Japan.
Yuya SekineDepartment of Urology, Akita University Graduate School of Medicine, Akita, Japan.
Hiromitsu NegoroDepartment of Urology, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Ryoma KurahashiDepartment of Urology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Kimihiro ShimataniDepartment of Urology, Hyogo Medical University, Hyogo, Japan.
Atsuro SawadaDepartment of Urology, Miyazaki University, Miyazaki, Japan.
Shusuke AkamatsuDepartment of Urology, Nagoya University, Nagoya, Aichi, Japan.
Takashi Kobayashi *Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan. selecao@kuhp.kyoto-u.ac.jp.
Takayuki Goto *Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan. goto@kuhp.kyoto-u.ac.jp.
The Daimonji Clinical Application Database Dai-Cad

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate functional and oncological outcomes in patients who underwent unilateral or bilateral nerve-sparing (NS) robot-assisted radical prostatectomy (RARP) for high-risk prostate cancer.

methodsThe cohort comprised 2683 patients with clinical stage T1-4, N0M0 high-risk prostate cancer who underwent RARP in Japanese tertiary care centers from August 2011 to April 2023. High risk was defined using the European Association of Urology risk stratification criteria. Patients were classified as high risk if they had clinical stage T2c-T4, a serum prostate-specific antigen concentration (PSA) of > 20 ng/dL, or an International Society of Urological Pathology (ISUP) grade of 4-5. Patients were grouped into NS and non-NS surgery groups. Propensity score matching was performed (1:1 ratio) to reduce confounding bias. The primary outcome was biochemical recurrence (BCR)-free survival (BCR-FS). The impact of NS surgery on BCR-FS was examined in the propensity score-matched cohort using Cox proportional hazards regression.

resultsThe propensity score-matched cohort comprised 1722 patients. In the matched cohort, median follow-up was 31.9 months. The 5-year BCR-FS was 70.2% in the NS group and 71.9% in the non-NS group (HR 1.05; 95% confidence interval, 0.85-1.29). NS surgery did not increase the risk of BCR in subgroups of patients stratified according to ISUP grade, T stage, percent cancer core involvement, and PSA.

conclusionNeurovascular bundle preservation during RARP for high-risk prostate cancer appears feasible without increasing the BCR rate. However, the retrospective study design carries the potential influence of selection bias.

Indexed as

Neoplasm Recurrence, LocalOrgan Sparing TreatmentsProstatectomyProstatic NeoplasmsRobotic Surgical ProceduresAgedCohort StudiesHumansMaleMiddle AgedNeoplasm StagingPropensity ScoreProstateProstate-Specific AntigenRetrospective StudiesRisk AssessmentProstate-Specific AntigenBiochemical recurrenceNerve sparingNeurovascular bundle preservationProstate cancerRobot‑assisted radical prostatectomy

Identifiers

PMID39708111

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.