Evidence map›Paper›PMID 39707985›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2024

Structure of subcortico-cortical tracts in middle-aged and older adults with autism spectrum disorder.

Michaela Cordova, Janice Hau, Adam Schadler, Molly Wilkinson, Kalekirstos Alemu, Ian Shryock, Ashley Baker, Chantal Chaaban, Emma Churchill, Inna Fishman and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Michaela CordovaBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, 6363 Alvarado Ct., San Diego, CA 92120, United States.ORCID 0000-0002-6860-5159
Janice HauBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, 6363 Alvarado Ct., San Diego, CA 92120, United States.ORCID 0000-0002-6919-1971
Adam SchadlerBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, 6363 Alvarado Ct., San Diego, CA 92120, United States.
Molly WilkinsonBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, 6363 Alvarado Ct., San Diego, CA 92120, United States.
Kalekirstos AlemuBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, 6363 Alvarado Ct., San Diego, CA 92120, United States.
Ian ShryockDepartment of Psychology, University of Oregon, Straub Hall, 1451 Onyx St., Eugene, OR, United States.
Ashley BakerBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, 6363 Alvarado Ct., San Diego, CA 92120, United States.
Chantal ChaabanBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, 6363 Alvarado Ct., San Diego, CA 92120, United States.
Emma ChurchillBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, 6363 Alvarado Ct., San Diego, CA 92120, United States.
Inna FishmanBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, 6363 Alvarado Ct., San Diego, CA 92120, United States.
Ralph-Axel MüllerBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, 6363 Alvarado Ct., San Diego, CA 92120, United States.
Ruth A CarperBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, 6363 Alvarado Ct., San Diego, CA 92120, United States.ORCID 0000-0002-1195-5473

Funding

The Autistic Brain Over 45: The Anatomic, Functional, and Cognitive PhenotypeR01MH103494 · NIMH · SAN DIEGO STATE UNIVERSITY · PI CARPER, RUTH, MUELLER, RALPH-AXEL · 2015 to 2025
$7.0M
National Science Foundation GRFP 1842470NIH HHS R01-MH103494NIMH NIH HHS R01 MH103494
6 · The paper itself

Abstract

Middle-aged and older adults with autism spectrum disorder may be susceptible to accelerated neurobiological changes in striato- and thalamo-cortical tracts due to combined effects of typical aging and existing disparities present from early neurodevelopment. Using magnetic resonance imaging, we employed diffusion-weighted imaging and automated tract-segmentation to explore striato- and thalamo-cortical tract microstructure and volume differences between autistic (n = 29) and typical comparison (n = 33) adults (40 to 70 years old). Fractional anisotropy, mean diffusivity, and tract volumes were measured for 14 striato-cortical and 12 thalamo-cortical tract bundles. Data were examined using linear regressions for group by age effects and group plus age effects, and false discovery rate correction was applied. Following false discovery rate correction, volumes of thalamocortical tracts to premotor, pericentral, and parietal regions were significantly reduced in autism spectrum disorder compared to thalamo-cortical groups, but no group by age interactions were found. Uncorrected results suggested additional main effects of group and age might be present for both tract volume and mean diffusivity across multiple subcortico-cortical tracts. Results indicate parallel rather than accelerated changes during adulthood in striato-cortical and thalamo-cortical tract volume and microstructure in those with autism spectrum disorder relative to thalamo-cortical peers though thalamo-cortical tract volume effects are the most reliable.

Indexed as

Autism Spectrum DisorderAdultAgedAgingCerebral CortexDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingFemaleHumansMaleMiddle AgedNeural PathwaysThalamusagingdevelopmental disordersdiffusiontractographywhite matter

Identifiers

PMID39707985
PMCPMC11662352

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.