ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2025
Time to Staphylococcus aureus Blood Culture Positivity as a Risk Marker of Infective Endocarditis: A Retrospective Cohort Study.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Rationalizing Heterogeneity in Staphylococcus aureus Bacteremia: Current Progress and Future Goals.The Journal of infectious diseases · 2026Review
- Transthoracic echocardiography in children withBMJ paediatrics open · 2026Article
- Article
- Phenotype-Based Stratification and Early Prediction of Staphylococcal Infective Endocarditis: Development of a Pragmatic Bedside Score.Pathogens (Basel, Switzerland) · 2026Article
- Article
- Analysis of Clinical Subphenotypes in Methicillin-ResistantOpen forum infectious diseases · 2025Article
- Fewer Minor Modified Duke Criteria on Admission Are Associated with Worse 90-Day Mortality in Patients with Confirmed Infective Endocarditis.Journal of clinical medicine · 2025Article
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6 authors.
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Abstract
backgroundEndocarditis occurs in approximately 10%-15% of patients with Staphylococcus aureus bacteremia (SAB). Short time to positivity (TTP) in blood culture flasks has been linked to endocarditis in smaller studies. This study evaluated the association between TTP and endocarditis in SAB in a large cohort.
methodsAdult patients with ≥1 S. aureus positive blood culture treated at a tertiary-level, 500-bed hospital in Stockholm, Sweden between 2011-2021 were retrospectively identified. The primary outcome was the presence of infective endocarditis.
resultsA total of 1703 episodes of SAB (23/1703 methicillin-resistant) in 1610 patients were included. Median age was 75 (interquartile range [IQR], 63-84) years and median Charlson comorbidity index score was 2 (IQR, 1-3). Echocardiography was performed in 1102/1703 (65%). Thirty-day mortality was 406/1703 (24%) and endocarditis was found in 154/1703 (9%). Median TTP was shorter in patients with endocarditis (9 [IQR, 7-12] hours) compared to patients without endocarditis (13 [interquartile range, 10-18] hours; P < .001). The risk of endocarditis decreased with 11% per hour (odds ratio [OR], 0.89 [95% confidence interval {CI}, .54-.92]; P < .001) in a univariate analysis using TTP as a continuous variable. In multivariate analysis, TTP <13 hours (the median) was independently associated with endocarditis (OR, 3.59 [95% CI, 2.35-5.3]; P < .001). The negative predictive value of TTP >13 hours for endocarditis was 96% (95% CI, 95%-97%).
conclusionsShort TTP was associated with endocarditis. The negative predictive value of >95% suggests that TTP >13 hours can be used to risk-stratify patients with SAB.
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