Evidence map›Paper›PMID 39707881›Full record

SynthesisTherapeutic advances in respiratory disease

Efficacy of behavioral cough suppression therapy for refractory chronic cough or unexplained chronic cough: a meta-analysis of randomized controlled trials.

Baiyi Yi, Shengyuan Wang, Xianghuai Xu, Li Yu

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Therapeutic advances in respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07070895 (A Prospective Decentralized Investigation of the Effect of a Cough Management Feature Inside a Wellness Application), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07070895 narecruitingnot on this map

A Prospective Decentralized Investigation of the Effect of a Cough Management Feature Inside a Wellness Application (CoughPro) in Refractory or Unexplained Chronic Cough (RCC/UCC)

TypeinterventionalSponsorHyfe IncRan2025 to 2025Enrolled20ConditionsRefractory Chronic Cough, Unexplained Chronic Cough, Cough HypersensitivityArmsCough Management, CoughMonitor Suite
3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. From Psychogenic Cough to Somatic Cough Syndrome.The clinical respiratory journal · 2026
    Review
  8. Article
  9. Cough and dyspnea management in pulmonary fibrosis.Current opinion in supportive and palliative care · 2025
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Baiyi YiDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0009-0006-5396-8228
Shengyuan WangDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0000-0003-1245-2998
Xianghuai XuDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, No. 389 Xincun Road, Shanghai 200065, China.ORCID 0000-0002-8713-5332
Li YuDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, No. 389 Xincun Road, Shanghai 200065, China.ORCID 0000-0002-1054-017X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe efficacy of behavioral cough suppression therapy (BCST) for refractory chronic cough (RCC) and unexplained chronic cough (UCC) remains unclear due to limited evidence from small-scale single-center studies.

objectiveTo compile and assess the quality of evidence from randomized controlled trials to evaluate the effectiveness of BCST.

designThis study included randomized controlled studies and self-controlled studies related to BCST involving adult patients with RCC or UCC. DATA SOURCES AND

methodsWe conducted an extensive search of various English and Chinese databases (e.g., PubMed, CNKI, CBM, VIP, and Wanfang Data Journal Full-text Database) and the Clinical Trial Registration website up to April 2024. The selected studies underwent meta-analysis to investigate the impact of BCST on the patient's quality of life and cough frequency.

resultsThe included 12 studies showed that BCST significantly improved the Leicester Cough Questionnaire scores of the patients (MD = 4.50, 95% CI (4.03, 4.97),

conclusionThis meta-analysis revealed positive therapeutic effects of BCST in patients with RCC/UCC, potentially advancing its application in broader clinical settings.

trial registrationThis study was registered on PROSPERO with the registration number

Indexed as

CoughQuality of LifeRandomized Controlled Trials as TopicAdultAgedBehavior TherapyChronic CoughChronic DiseaseFemaleHumansMaleMiddle AgedTreatment Outcomebehavioral cough suppression therapychronic coughcough frequencyLCQ scoresmeta-analysis

Identifiers

PMID39707881
PMCPMC11663276

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.