Evidence map›Paper›PMID 39707707›Full record

ArticleEpigenomics2025

Religion, spirituality, and DNA methylation in HPA-axis genes among Hispanic/Latino adults.

Jenny Zhen-Duan, Katia M Canenguez, Anna E Wilson, Yue Gu, Harshitha G Valluri, Alejandra D Chavez, M Austin Argentieri, Anna Boonin Schachter, Haotian Wu, Andrea A Baccarelli and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jenny Zhen-DuanDisparities Research Unit, Mongan Institute, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-5870-2617
Katia M CanenguezDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
Anna E WilsonDisparities Research Unit, Mongan Institute, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Yue GuHarvard/MGH Center on Genomics, Vulnerable Populations, and Health Disparities, Mongan Institute, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Harshitha G ValluriDepartment of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA.
Alejandra D ChavezDisparities Research Unit, Mongan Institute, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
M Austin ArgentieriHarvard/MGH Center on Genomics, Vulnerable Populations, and Health Disparities, Mongan Institute, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Anna Boonin SchachterHarvard/MGH Center on Genomics, Vulnerable Populations, and Health Disparities, Mongan Institute, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Haotian WuDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
Andrea A BaccarelliDepartment of Environmental Health, Harvard T H Chan School of Public Health, Boston, MA, USA.
Martha L DaviglusInstitute for Minority Health Research, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.
Sylvia Wassertheil-SmollerDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, New York, NY, USA.
Erica T WarnerHarvard/MGH Center on Genomics, Vulnerable Populations, and Health Disparities, Mongan Institute, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Alexandra E ShieldsHarvard/MGH Center on Genomics, Vulnerable Populations, and Health Disparities, Mongan Institute, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.

Funding

Latino Youths Coping with Discrimination: A Multi-Level Investigation in Micro- and Macro-Time admin supplementR01MD014737 · NIMHD · MASSACHUSETTS GENERAL HOSPITAL · PI ALEGRIA, MARGARITA · 2020 to 2024
$3.4M
Adverse childhood experiences and alcohol misuse in Latino adolescents: testing biopsychosocial and cultural mechanisms supplementK08AA029150 · NIAAA · MASSACHUSETTS GENERAL HOSPITAL · PI Jenny Zhen-Duan · 2022 to 2026
$957k
HISPANIC COMMUNITY HEALTH STUDY-268065233N01HC065233 · HC · COORDINATING CENTER · PI CHAMBLESS, LLOYD E · 2006 to 2006
–
NHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NIAAA NIH HHS K08 AA029150NIMHD NIH HHS R01 MD014737
6 · The paper itself

Abstract

aimInvestigate associations between religion and spirituality (R&S) and DNA methylation of four HPA-axis genes (i.e. 14 CpG sites) among 992 adults from the Hispanic Community Health Study/Study of Latinos cohorts.

methodsWe assessed 1) the association between R&S measures and mean percent methylation overall and stratified by nativity status (US-born or immigrant) and 2) if interactions between R&S and methylation differed by nativity status.

resultsAmong individuals with the

conclusionR&S may influence HPA-axis functioning differently based on nativity status; a finding that could offer insight into mechanisms leading to health disparities.

Indexed as

DNA MethylationHispanic or LatinoHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemReligionSpiritualityAdultCpG IslandsFemaleHumansMaleMiddle AgedTacrolimus Binding Protein 5Tacrolimus Binding ProteinsUnited StatesTacrolimus Binding Protein 5Tacrolimus Binding ProteinsDNA methylationHispanic/LatinoHPA-axisimmigrantsreligion and spiritualitystress

Identifiers

PMID39707707
PMCPMC11812325

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.