Evidence map›Paper›PMID 39707492›Full record

ArticleStem cell research & therapy2024

Human neural stem cells directly programmed from peripheral blood show functional integration into the adult mouse brain.

Lea Jessica Berg, Chung Ku Lee, Hideaki Matsumura, Anke Leinhaas, Rachel Konang, Ali H Shaib, Pedro Royero, Julia Schlee, Chao Sheng, Heinz Beck and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lea Jessica Berg *Institute of Reconstructive Neurobiology, University of Bonn Medical Faculty and University Hospital Bonn, Venusberg-Campus 1, Bonn, 53127, Germany.
Chung Ku Lee *Department of Molecular Neurobiology, Max-Planck-Institute for Multidisciplinary Sciences, City Campus, Hermann-Rein-Str. 3, Göttingen, 37075, Germany.
Hideaki MatsumuraInstitute of Reconstructive Neurobiology, University of Bonn Medical Faculty and University Hospital Bonn, Venusberg-Campus 1, Bonn, 53127, Germany.
Anke LeinhaasInstitute of Reconstructive Neurobiology, University of Bonn Medical Faculty and University Hospital Bonn, Venusberg-Campus 1, Bonn, 53127, Germany.
Rachel KonangInstitute of Reconstructive Neurobiology, University of Bonn Medical Faculty and University Hospital Bonn, Venusberg-Campus 1, Bonn, 53127, Germany.
Ali H ShaibDepartment of Molecular Neurobiology, Max-Planck-Institute for Multidisciplinary Sciences, City Campus, Hermann-Rein-Str. 3, Göttingen, 37075, Germany.
Pedro RoyeroInstitute of Experimental Epileptology and Cognition Research, University of Bonn Medical Faculty and University Hospital Bonn, Venusberg-Campus 1, Bonn, 53127, Germany.
Julia SchleeInstitute of Reconstructive Neurobiology, University of Bonn Medical Faculty and University Hospital Bonn, Venusberg-Campus 1, Bonn, 53127, Germany.
Chao ShengInstitute of Reconstructive Neurobiology, University of Bonn Medical Faculty and University Hospital Bonn, Venusberg-Campus 1, Bonn, 53127, Germany.
Heinz BeckInstitute of Experimental Epileptology and Cognition Research, University of Bonn Medical Faculty and University Hospital Bonn, Venusberg-Campus 1, Bonn, 53127, Germany.
Martin Karl SchwarzInstitute of Experimental Epileptology and Cognition Research, University of Bonn Medical Faculty and University Hospital Bonn, Venusberg-Campus 1, Bonn, 53127, Germany.
Nils BroseDepartment of Molecular Neurobiology, Max-Planck-Institute for Multidisciplinary Sciences, City Campus, Hermann-Rein-Str. 3, Göttingen, 37075, Germany.
Jeong Seop RheeDepartment of Molecular Neurobiology, Max-Planck-Institute for Multidisciplinary Sciences, City Campus, Hermann-Rein-Str. 3, Göttingen, 37075, Germany.
Oliver BrüstleInstitute of Reconstructive Neurobiology, University of Bonn Medical Faculty and University Hospital Bonn, Venusberg-Campus 1, Bonn, 53127, Germany. brustle@uni-bonn.de.ORCID 0000-0002-1277-0980

Funding

Deutsche Forschungsgemeinschaft 227953431Horizon 2020 Framework Programme 66730Horizon 2020 Framework Programme 874758Ibaraki Prefecture Global Human Resource Development ProgramJapan Society for the Promotion of Science Overseas Research FellowshipUehara Memorial Foundation Research fellowship
6 · The paper itself

Abstract

Transplantation of induced pluripotent stem cell-derived neural cells represents a promising strategy for treating neurodegenerative diseases. However, reprogramming of somatic cells and their subsequent neural differentiation is complex and time-consuming, thereby impeding autologous applications. Recently, direct transcription factor-based conversion of blood cells into induced neural stem cells (iNSCs) has emerged as a potential alternative. However, little is known about the functionality of iNSC-derived neurons upon in vivo transplantation. Here, we grafted human iNSCs derived from adult peripheral blood by temporary overexpression of the transcription factors SOX2 and cMYC into the hippocampus or striatum of adult unlesioned immunodeficient Rag2

Indexed as

Neural Stem CellsAnimalsBrainCell DifferentiationExcitatory Postsynaptic PotentialsFemaleHippocampusHumansInduced Pluripotent Stem CellsMaleMiceNeuronsSOXB1 Transcription FactorsSOXB1 Transcription FactorsCell programmingDirect conversionInduced neural stem cellsNeural network integrationTransplantation

Identifiers

PMID39707492
PMCPMC11662720

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.