Evidence map›Paper›PMID 39707453›Full record

ArticleStem cell research & therapy2024

Impact of photobiomodulation on neural embryoid body formation from immortalized adipose-derived stem cells.

Precious Earldom Mulaudzi, Heidi Abrahamse, Anine Crous

Abstract read
In one paragraph

Article in Stem cell research & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Precious Earldom MulaudziLaser Research Centre, Faculty of Health Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, 2028, South Africa.
Heidi AbrahamseLaser Research Centre, Faculty of Health Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, 2028, South Africa.
Anine CrousLaser Research Centre, Faculty of Health Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, 2028, South Africa. acrous@uj.ac.za.ORCID 0000-0002-7581-7731

Funding

Department of Science and Innovation (DSI) funded African Laser Centre (ALC) HLHA23X task ALC-R007Department of Science and Innovation South African Research Chairs Initiative (DSI-NRF/SARChI) 98337National Research Foundation Doctoral Grant PMDS22070532778National Research Foundation of South Africa Thuthuka Instrument TTK2205035996University Research Council 2022URC00513
6 · The paper itself

Abstract

backgroundEmbryoid bodies (EBs) are three-dimensional (3D) multicellular cell aggregates that are derived from stem cell and play a pivotal role in regenerative medicine. They recapitulate many crucial aspects of the early stages of embryonic development and is the first step in the generation of various types of stem cells, including neuronal stem cells. Current methodologies for differentiating stem cells into neural embryoid bodies (NEBs) in vitro have advanced significantly, but they still have limitations which necessitate improvement. Photobiomodulation (PBM) a low powered light therapy is a non-invasive technique shown to promote stem cell proliferation and differentiation.

methodsThis in vitro study elucidated the effects of photobiomodulation (PBM) on the differentiation of immortalized adipose-derived stem cells (iADSCs) into NEBs within a 3D cell culture environment. The study utilized PBM at wavelengths of 825 nm, 525 nm, and a combination of both, with fluences of 5 and 10 J/cm

resultsThe results revealed that the effects of photobiomodulation (PBM) are dose dependent. PBM, at 825 nm with a fluence of 10 J/cm

conclusionIn conclusion, the application of PBM at 825 nm with a fluence of 10 J/cm

Indexed as

Cell DifferentiationEmbryoid BodiesLow-Level Light TherapyAdipose TissueCell ProliferationCell SurvivalHumansNeural Stem CellsCell differentiationNeural embryoid bodyPhotobiomodulationStem cells

Identifiers

PMID39707453
PMCPMC11662703

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.