Evidence map›Paper›PMID 39707381›Full record

ArticleAnnals of clinical microbiology and antimicrobials2024

Tracing the transmission of carbapenem-resistant Enterobacterales at the patient: ward environmental nexus.

Linzy Elton, Alan Williams, Shanom Ali, Jelena Heaphy, Vicky Pang, Liam Commins, Conor O'Brien, Özge Yetiş, Estelle Caine, Imogen Ward and 8 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical microbiology and antimicrobials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Linzy EltonThe Centre for Clinical Microbiology, University College London, London, UK. linzy.elton@ucl.ac.uk.
Alan WilliamsDepartment of Infection Sciences, Health Services Laboratories, London, UK.
Shanom AliThe Centre for Clinical Microbiology, University College London, London, UK.
Jelena HeaphyRoyal Free London NHS Foundation Trust, London, UK.
Vicky PangRoyal Free London NHS Foundation Trust, London, UK.
Liam ComminsRoyal Free London NHS Foundation Trust, London, UK.
Conor O'BrienRoyal Free London NHS Foundation Trust, London, UK.
Özge YetişThe Centre for Clinical Microbiology, University College London, London, UK.
Estelle CaineEnvironmental Research Laboratory, University College London Hospitals NHS Foundation Trust, London, UK.
Imogen WardEnvironmental Research Laboratory, University College London Hospitals NHS Foundation Trust, London, UK.
Monika MuzslayEnvironmental Research Laboratory, University College London Hospitals NHS Foundation Trust, London, UK.
Samuel YuiEnvironmental Research Laboratory, University College London Hospitals NHS Foundation Trust, London, UK.
Kush KariaEnvironmental Research Laboratory, University College London Hospitals NHS Foundation Trust, London, UK.
Ellinor ShoreDepartment of Infection Sciences, Health Services Laboratories, London, UK.
Sylvia RofaelThe Centre for Clinical Microbiology, University College London, London, UK.
Damien J F MackRoyal Free London NHS Foundation Trust, London, UK.
Timothy D McHughThe Centre for Clinical Microbiology, University College London, London, UK.
Emmanuel Q WeyThe Centre for Clinical Microbiology, University College London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionColonisation and infection with Carbapenem-resistant Enterobacterales (CRE) in healthcare settings poses significant risks, especially for vulnerable patients. Genomic analysis can be used to trace transmission routes, supporting antimicrobial stewardship and informing infection control strategies. Here we used genomic analysis to track the movement and transmission of CREs within clinical and environmental samples.

methods25 isolates were cultured from clinical patient samples or swabs, that tested positive for OXA-48-like variants using the NG-Test® CARBA-5 test and whole genome sequenced (WGS) using Oxford Nanopore Technologies (ONT). 158 swabs and 52 wastewater samples were collected from the ward environment. 60 isolates (matching clinical isolate genera; Klebsiella, Enterobacter, Citrobacter and Escherichia) were isolated from the environmental samples using selective agar. Metagenomic sequencing was undertaken on 36 environmental wastewater and swab samples.

results21/25 (84%) clinical isolates had > 1 bla

conclusionsPotential for putative patient-patient and patient-ward transmission was shown. Metagenomic sampling needs optimization to improve sensitivity.

Indexed as

beta-LactamasesCarbapenem-Resistant EnterobacteriaceaeEnterobacteriaceae InfectionsWastewaterWhole Genome SequencingAnti-Bacterial AgentsBacterial ProteinsCarbapenemsCross InfectionEnterobacterHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesCarbapenemsWastewaterAntimicrobial resistanceCarbapenem-resistant EnterobacteralesCREEnvironmentHospitalMetagenomicsNDMOXA48Oxford NanoporePlasmidsTransmission

Identifiers

PMID39707381
PMCPMC11662836

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.