ArticleJournal of translational medicine2024
Disruption of gamete fusion alters the sperm-egg ratio at gamete interaction.
Article in Journal of translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Molecular interplay between sperm and oocyte: a narrative review.Human reproduction update · 2026Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
backgroundThe mechanisms enabling sperm to locate unfertilized eggs within the fallopian tubes remain a subject of debate in reproductive biology. Previous studies using polytocous mammals observed a 1:1 sperm-egg ratio within the ampulla at the time of fertilization. From these observations, it is hypothesized that this mechanism could be linked to sperm-egg fusion, such that unfertilized eggs may attract sperm until fusion occurs, whereupon the attraction ceases.
methodsTo test this, fertile male mice were mated with infertile homozygous Cd9
resultsThe results revealed that both Cd9
conclusionsThese findings indicate that genetic ablation of Cd9 leads to an imbalance in the 1:1 sperm-egg ratio observed within the ampulla. This information may set the foundation for future studies with the aim to identify the specific mechanisms that sperm use to locate unfertilized eggs and whether they become ineffective when gamete fusion is prevented.
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Registered trials
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