Evidence map›Paper›PMID 39707320›Full record

ArticleHealth and quality of life outcomes2024

Clinical importance of patient-reported outcome measures in severe asthma: results from U-BIOPRED.

Roy Meys, Frits M E Franssen, Alex J Van 't Hul, Per S Bakke, Massimo Caruso, Barbro Dahlén, Stephen J Fowler, Thomas Geiser, Peter H Howarth, Ildikó Horváth and 19 more

Abstract read
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In one paragraph

Article in Health and quality of life outcomes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Roy MeysDepartment of Research and Development, Hornerheide 1, 6085 NM, Ciro, Horn, The Netherlands. roymeys@ciro-horn.nl.
Frits M E FranssenDepartment of Research and Development, Hornerheide 1, 6085 NM, Ciro, Horn, The Netherlands.
Alex J Van 't HulDepartment of Pulmonary Diseases, Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.
Per S BakkeDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Massimo CarusoDepartment of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
Barbro DahlénLung/Allergy Clinic, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Stephen J FowlerDivision of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, NIHR Biomedical Research Centre, University of Manchester and Manchester Academic Health Science Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, UK.
Thomas GeiserDepartment of Pulmonary Medicine, University Hospital and University of Bern, Bern, Switzerland.
Peter H HowarthNIHR Southampton Biomedical Research Centre, Faculty of Medicine, University of Southampton, Southampton, UK.
Ildikó HorváthDepartment of Pulmonology, Semmelweis University, Budapest, Hungary.
Norbert KrugFraunhofer Institute for Toxicology and Experimental Medicine Hannover, Hannover, Germany.
Annelie F BehndigDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Florian SingerPaediatric Respiratory Medicine, Children's University Hospital of Bern, University of Bern, Bern, Switzerland.
Jacek MusialDepartment of Medicine, Jagiellonian University Medical College, Krakow, Poland.
Dominick E ShawRespiratory Research Unit, University of Nottingham, Nottingham, UK.
Paolo MontuschiCatholic University of the Sacred Heart, Rome, Italy.
Anke H Maitland-van der ZeeAmsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Peter J SterkAmsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Graham RobertsNIHR Southampton Biomedical Research Centre, Faculty of Medicine, University of Southampton, Southampton, UK.
Nazanin Z KermaniNational Heart and Lung Institute, Imperial College, London, UK.
Raffaele A IncalziUniversità Campus Bio-Medico IT, Rome, Italy.
Renaud LouisDepartment of Respiratory Medicine, GIGA I 3, CHU Sart-TilmanB35, University of Liege, Liege, Belgium.
Lars I AnderssonInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Scott S WagersBioSci Consulting, Maasmechelen, Belgium.
Sven-Erik DahlénInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Kian Fan ChungNational Heart and Lung Institute, Imperial College, London, UK.
Ian M AdcockNational Heart and Lung Institute, Imperial College, London, UK.
Martijn A SpruitDepartment of Research and Development, Hornerheide 1, 6085 NM, Ciro, Horn, The Netherlands.
U-BIOPRED Study Group

Funding

Lung Foundation Netherlands 5.1.18.232
6 · The paper itself

Abstract

rationaleKnowledge about the clinical importance of patient-reported outcome measures (PROMs) in severe asthma is limited.

objectivesTo assess whether and to what extent asthma exacerbations affect changes in PROMS over time and asthma-specific PROMs can predict exacerbations in adult patients with severe asthma in usual care.

methodsData of 421 patients with severe asthma (62% female; mean age 51.9 ± 13.4 years; mean FEV

resultsPROMs showed very weak to weak correlations with clinical characteristics such as age, body mass index, FEV

conclusionsThe association of PROMs with clinical measures was poor in severe asthmatics. Moreover, PROMs were prone to changes in usual care, with exacerbations playing a key role. PROMs need to be systematically evaluated in severe asthma to improve clinical care based on specific patient's needs.

Indexed as

AsthmaPatient Reported Outcome MeasuresQuality of LifeAdultClinical RelevanceFemaleHumansMaleMiddle AgedSeverity of Illness IndexSurveys and QuestionnairesHealth statusObstructive pulmonary diseasesPatient outcome assessment

Identifiers

PMID39707320
PMCPMC11662558

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.