ArticleBMC complementary medicine and therapies2024
Postbiotic metabolites derived from lactobacillus fermentum as potent antiproliferative bioresources on HeLa cells with promising biocompatibility.
Article in BMC complementary medicine and therapies, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Probiotic cell-free supernatants as a strategy against antimicrobial resistance: a systematic review.Frontiers in cellular and infection microbiology · 2026Pooled it
- Synergistic Anti-Lung Cancer Effects of Cytarabine and a NCBI-RegisteredFood science & nutrition · 2026Article
- Deciphering the Anticancer Potential of Bifidobacterium longum MB BBLM15 Derived Postbiotic Metabolites in Cervical Cancer: In Vitro, In Silico, and Synergy Studies.Probiotics and antimicrobial proteins · 2026Article
- Bifidobacterium enhances the antitumor efficacy of carboplatin in glioblastoma cells: targeting apoptotic and cell cycle regulatory pathways via Caspase, AKT/PTEN, and P53/P21 signaling.Cancer cell international · 2025Article
- Probiotic-enhanced chemotherapy: Lactobacillus fermentum synergizes with vincristine to induce apoptosis via dual pathway activation in human cancer cells.Cancer cell international · 2025Article
- Combinational therapy of cervical cancer consisting of probiotic particles and vincristine: a molecular in vitro study.Medical oncology (Northwood, London, England) · 2025Article
- In vitro cytotoxic and pro-apoptotic effects of Chaetoceros socialis ethanolic extract on prostate (LNCap) and glioblastoma (U-87 MG) cells via modulation of AKT/PTEN, mTOR, BAX/BCL2, and Caspase pathways.Medical oncology (Northwood, London, England) · 2025Article
- Postbiotics of Marine Origin and Their Therapeutic Application.Marine drugs · 2025Review
- Inhibitory effects of tetraselmis algae extract on cervical cancer cell proliferation: a molecular and cellular approach.Molecular biology reports · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
Chemotherapy administrations for cervical malignancy possess a variety of unfavorable influences on the human body. Scientists are interested in microbial-derived biomolecules or postbiotics as an alternative therapeutic strategy in malignant patients. This research investigated the mechanisms related to the function of two potential postbiotic Lactobacillus isolates, Lactobacillus fermentum CH and L. fermentum KH, isolated from indigenous Iranian dairy products. The Lactobacillus isolates were recognized through 16S rDNA sequence analysis followed by characterization using morphological and biochemical assays. The bioactivity of postbiotics on the cervical cancer model was also assessed through a cytotoxic study and apoptosis analysis. In addition, the anticancer activity was evaluated by qPCR, followed by a confirmation of the flow cytometry. The results of the bioactivity assay revealed that these postbiotics had suitable anticancer influences on the cervical cancer model (HeLa cells) by increasing BAX, caspase8, and caspase9, followed by a decrease in BCl-2, iKB (Inhibitor of nuclear factor kappa-B), and RelA gene expressions. Thus, the findings of this study signify that the postbiotic derivate from Lactobacillus strains isolated from indigenous Iranian dairy products could be regarded as a topical treatment with a promising curative index due to their effectiveness on cervical malignancy cells.
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