Evidence map›Paper›PMID 39707240›Full record

ArticleBMC cardiovascular disorders2024

Strain echocardiography predictors in patients with concomitant cardiac amyloidosis and aortic stenosis: a cross-sectional study.

Samira Jafarisis, Shahab Masoumi, Naser Khezerlouy-Aghdam, Kia Seyed Toutounchi, Amirreza Jabbaripour Sarmadian, Sina Hamzehzadeh, Akram Shariati, Razieh Parizad, Venus Shahabi Rabori

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Samira JafarisisCardiovascular Research Center, Tabriz University of Medical Sciences, Daneshgah Street, Tabriz, Eastern Azerbaijan, Iran.ORCID 0000-0001-5431-3860
Shahab MasoumiCardiovascular Research Center, Tabriz University of Medical Sciences, Daneshgah Street, Tabriz, Eastern Azerbaijan, Iran. masoumishawn@gmail.com.ORCID 0000-0002-3855-192X
Naser Khezerlouy-AghdamCardiovascular Research Center, Tabriz University of Medical Sciences, Daneshgah Street, Tabriz, Eastern Azerbaijan, Iran.ORCID 0000-0001-5446-1492
Kia Seyed ToutounchiCardiovascular Research Center, Tabriz University of Medical Sciences, Daneshgah Street, Tabriz, Eastern Azerbaijan, Iran.ORCID 0000-0002-6782-8342
Amirreza Jabbaripour SarmadianCardiovascular Research Center, Tabriz University of Medical Sciences, Daneshgah Street, Tabriz, Eastern Azerbaijan, Iran.ORCID 0000-0001-7677-8458
Sina HamzehzadehCardiovascular Research Center, Tabriz University of Medical Sciences, Daneshgah Street, Tabriz, Eastern Azerbaijan, Iran.ORCID 0000-0001-5344-4885
Akram ShariatiDepartment of Cardiology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.ORCID 0000-0002-9895-4018
Razieh ParizadCardiovascular Research Center, Tabriz University of Medical Sciences, Daneshgah Street, Tabriz, Eastern Azerbaijan, Iran.ORCID 0000-0002-4492-637X
Venus Shahabi RaboriCardiology Department, Royal Albert Edward Infirmary, WWL NHS Trust, Wigan, UK.ORCID 0000-0002-2589-5360

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundConcomitant cardiac amyloidosis (CA) and aortic stenosis (AS) may be mistaken for isolated AS, potentially impacting the treatment strategy and patient's prognosis. Therefore, it is crucial to distinguish between these conditions, as failure to promptly diagnose CA may lead to considerable complications. The aim of this study is to investigate the diagnostic value of strain predictors in patients with concomitant CA and AS compared to isolated AS.

methodsForty-two patients with severe AS suspected of concomitant CA based on a comprehensive clinical evaluation were selected to undergo

resultsEight patients were diagnosed with CA, representing 19.0% of those suspected of concomitant CA and 7.8% of the overall cohort with severe AS. AF arrhythmia was significantly more frequent in these patients compared to those with isolated AS. Echocardiography findings revealed that E/E' ratio and RALS were significantly higher in patients with concomitant CA, while GLS and mean basal LS were significantly lower in this group. The "cherry on top" sign was detected in 19 patients (45.2%), present in 100% of those with concomitant CA and AS, versus 32.4% in isolated AS cases (P = 0.04). This sign demonstrated a sensitivity of 100% and a specificity of 67.6% for predicting concomitant CA and AS.

conclusionsIn conclusion, the "cherry on top" sign was significantly more prevalent in patients with concomitant CA and AS, compared to those with isolated AS, demonstrating a sensitivity of 100% and a specificity of 67.6% for predicting concomitant CA. Moreover, RALS and E/E' ratios were significantly higher in patients with concomitant CA, whereas GLS and mean basal LS were significantly lower in this group.

Indexed as

AmyloidosisAortic Valve StenosisCardiomyopathiesPredictive Value of TestsAgedAged, 80 and overCross-Sectional StudiesDiagnosis, DifferentialEchocardiographyFemaleHumansMaleMiddle AgedMyocardial ContractionReproducibility of ResultsSeverity of Illness IndexAmyloidosisAortic stenosisEchocardiographyStrain

Identifiers

PMID39707240
PMCPMC11660616

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