ArticleBMC cardiovascular disorders2024
Independent prognostic importance of the albumin-corrected anion gap in critically ill patients with congestive heart failure: a retrospective study from MIMIC-IV database.
Article in BMC cardiovascular disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- Association of ACAG with short-term mortality in liver failure patients: a retrospective analysis based on the MIMIC-IV database.Scientific reports · 2026Article
- Association between albumin-corrected anion gap and 28-day mortality in critically ill patients with pneumonia in the intensive care unit: evidence from the medical information mart for intensive care IV database.BMC pulmonary medicine · 2026Observational
- Stress hyperglycemia ratio in risk stratification and treatment optimization for patients on invasive mechanical ventilation: a secondary analysis of the MIMIC-IV database.BMC infectious diseases · 2026Article
- Machine Learning-Based Nomogram with Boruta and LASSO for 28-Day Mortality Prediction in Critical COPD Patients: Role of the Albumin-Corrected Anion Gap.International journal of chronic obstructive pulmonary disease · 2026Article
- Association Between Albumin-Corrected Anion Gap and Mortality in ICU Patients With Acute Heart Failure: A MIMIC-IV Cohort Study.Cardiovascular therapeutics · 2026Article
- Predictive Value of 48-hour Anion Gap Fluctuations in ICU Patients with Acute Kidney Injury: An Analysis based on MIMIC Database.Current pharmaceutical design · 2026Article
- Albumin-corrected anion gap and risk of mortality among US adults.Archives of public health = Archives belges de sante publique · 2025Article
- Prognostic value of albumin-corrected anion gap in severe chronic kidney disease with sepsis: association with mortality and clinical outcomes.European journal of medical research · 2025Article
- Association of albumin-corrected anion gap with mortality in ICU patients with heart failure and acute kidney injury: analysis of the MIMIC-IV database.European journal of medical research · 2025Article
- Development, Validation, and Deployment of a Time-Dependent Machine Learning Model for Predicting One-Year Mortality Risk in Critically Ill Patients with Heart Failure.Bioengineering (Basel, Switzerland) · 2025Article
- Article
- Independent prognostic importance of endothelial activation and stress index (EASIX) in critically ill patients with heart failure: modulating role of inflammation.Frontiers in medicine · 2025Article
- Relationship between albumin-corrected anion gap and short- and medium-term all-cause mortality in heart failure patients with a single ICU admission.Frontiers in cardiovascular medicine · 2025Article
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3 authors.
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Abstract
backgroundThe associations between the albumin-corrected anion gap (ACAG) and all-cause mortality in patients with congestive heart failure in the intensive care unit remain uncertain. This study aimed to investigate this unknown.
methodsThe MIMIC-IV (version 3.0) database was used to analyze critically ill patients with congestive heart failure. Patients were grouped into tertiles (T1-T3) on the basis of the ACAG. The association between ACAG levels and 1-year all-cause mortality was assessed using Kaplan-Meier survival analyses, multivariate adjusted Cox regression models, and restricted cubic spline curves. An analysis of subgroups was performed to evaluate ACAG's prognostic impact across diverse populations. Mediation analysis was conducted to identify and elucidate potential causal pathways linking ACAG to all-cause mortality.
resultsA cohort of 7787 patients was analyzed. On the basis of Kaplan-Meier curves, Cox regression, restricted cubic spline curves and subgroup analysis, T2 (hazard ratio 1.09, 95% confidence interval 1.02 ~ 1.16) and T3 (hazard ratio 1.25, 95% confidence interval 1.17 ~ 1.33) individuals presented a greater mortality risk compared to T1 individuals (p for linear trend < 0.001), and most subgroups consistently observed this relationship, except for those with different levels of left ventricular ejection fraction. Mediation analysis indicated that the red cell distribution width, stage of acute kidney injury, chloride and acute physiology score III partially mediated the relationship between ACAG and mortality, accounting for 12.4%, 7.0%, 12.9%, and 31.2% of the mediating effect, respectively.
conclusionsThe ACAG was associated with higher 1-year all-cause mortality in critically ill patients with congestive heart failure, with stronger impact in those with lower left ventricular ejection fractions. The ACAG may serve as an indicator in high-risk groups. CLINICAL TRIAL NUMBER: Not applicable.
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