Evidence map›Paper›PMID 39707197›Full record

ArticleGenetics, selection, evolution : GSE2024

Haplotype analysis incorporating ancestral origins identified novel genetic loci associated with chicken body weight using an advanced intercross line.

Lina Bu, Yuzhe Wang, Lizhi Tan, Zilong Wen, Xiaoxiang Hu, Zhiwu Zhang, Yiqiang Zhao

Abstract read
In one paragraph

Article in Genetics, selection, evolution : GSE, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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  3. Genes · 2025
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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Lina Bu *State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Yuzhe Wang *State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Lizhi TanState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Zilong WenState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Xiaoxiang HuState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Zhiwu ZhangDepartment of Crop and Soil Sciences, Washington State University, Pullman, WA, USA.
Yiqiang ZhaoState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China. yiqiangz@cau.edu.cn.

Funding

Biological Breeding-National Science and Technology Major Project 2023ZD04069the National Key Research and Development Program of China 2021YFD1200803the National Key Research and Development Program of China 2022YFF1000204
6 · The paper itself

Abstract

backgroundThe genome-wide association study (GWAS) is a powerful method for mapping quantitative trait loci (QTL). However, standard GWAS can detect only QTL that segregate in the mapping population. Crossing populations with different characteristics increases genetic variability but F2 or back-crosses lack mapping resolution due to the limited number of recombination events. This drawback can be overcome with advanced intercross line (AIL) populations, which increase the number recombination events and provide a more accurate mapping resolution. Recent studies in humans have revealed ancestry-dependent genetic architecture and shown the effectiveness of admixture mapping in admixed populations.

resultsThrough the incorporation of line-of-origin effects and GWAS on an F

conclusionsIn addition to the candidate genes reported in this study, our research demonstrates the effectiveness of incorporating ancestral information in population genetic analyses, which can be broadly applicable for genetic mapping in populations generated by ancestors with distinct phenotypes and genetic backgrounds. Our methods can benefit both geneticists and biologists interested in the genetic determinism of complex traits.

Indexed as

Body WeightChickensGenome-Wide Association StudyHaplotypesQuantitative Trait LociAnimalsChromosome MappingCrosses, GeneticFemaleMalePolymorphism, Single Nucleotide

Identifiers

PMID39707197
PMCPMC11660596

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.