Evidence map›Paper›PMID 39707126›Full record

Observational studyLa Radiologia medica2025

Radioembolization for Hepatocellular Carcinoma: a Comparison on Dual-phase Cone-beam CT, Contrast-enhanced CT (CECT) and

Ettore di Gaeta, Michela Olivieri, Annarita Savi, Patrizia Magnani, Carla Canevari, Simone Gusmini, Diego Palumbo, Giorgia Guazzarotti, Luigi Augello, Francesca Calabrese and 7 more

Erratum issued Registry-linked trialAbstract readObservational Study
In one paragraph

Observational study in La Radiologia medica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03981497 (Retrospective and Perspective Analysis of Short, Medium and Long Term Clinical Performance of Patients Undergoing MicrowaveThermal Ablation for Treatment of Small Renal Tumors and Primary and Secondary Liver Neoplasms), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03981497 recruitingnot on this map

Retrospective and Perspective Analysis of Short, Medium and Long Term Clinical Performance of Patients Undergoing MicrowaveThermal Ablation for Treatment of Small Renal Tumors and Primary and Secondary Liver Neoplasms

TypeobservationalSponsorFrancesco De CobelliRan2018 to 2030Enrolled500ConditionsLiver Cancer, Liver Metastasis Colon Cancer, Kidney Cancer, Renal Cell CarcinomaArmsMicrowave ablation (MWA)
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Ettore di GaetaDepartment of Radiology, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID http://orcid.org/0009-0002-9288-7966
Michela OlivieriDepartment of Nuclear Medicine, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID http://orcid.org/0009-0000-2344-3865
Annarita SaviDepartment of Nuclear Medicine, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID http://orcid.org/0000-0001-6347-632X
Patrizia MagnaniDepartment of Nuclear Medicine, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID http://orcid.org/0000-0001-5716-7213
Carla CanevariDepartment of Nuclear Medicine, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID http://orcid.org/0000-0002-1288-1461
Simone GusminiDepartment of Radiology, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID http://orcid.org/0009-0004-4086-3713
Diego PalumboDepartment of Radiology, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID http://orcid.org/0000-0002-7906-540X
Giorgia GuazzarottiDepartment of Radiology, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID http://orcid.org/0000-0002-6535-1720
Luigi AugelloDepartment of Radiology, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID http://orcid.org/0000-0002-3070-6632
Francesca CalabreseDepartment of Radiology, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID http://orcid.org/0000-0002-3293-4663
Stephanie SteidlerDepartment of Radiology, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID http://orcid.org/0000-0002-4441-7962
Federica CiprianiDepartment of Hepatobiliary Surgery, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID http://orcid.org/0000-0002-8651-5982
Margherita RiminiSchool of Medicine, Vita-Salute San Raffaele University, Milan, Italy.ORCID http://orcid.org/0000-0002-4047-2585
Andrea Casadei-GardiniSchool of Medicine, Vita-Salute San Raffaele University, Milan, Italy.ORCID http://orcid.org/0000-0001-6289-7202
Luca AldrighettiSchool of Medicine, Vita-Salute San Raffaele University, Milan, Italy.ORCID http://orcid.org/0000-0001-7729-2468
Arturo ChitiDepartment of Nuclear Medicine, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID http://orcid.org/0000-0002-5806-1856
Francesco De CobelliDepartment of Radiology, IRCCS Ospedale San Raffaele, Milan, Italy. decobelli.francesco@hsr.it.ORCID http://orcid.org/0000-0003-4014-3711

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePersonalized treatment schemes are being systematically applied to ensure best treatment outcome in oncologic patients. This is true also for personalized dosimetry in transarterial radioembolization (TARE) in hepatocellular carcinoma (HCC) patients. Precise and detailed volumetric and functional data derived from radiological and nuclear imaging methods are essential for personalized dosimetry. We sought to evaluate accuracy of dual-phase cone-beam CT (CBCT) in comparison to pre-treatment contrast-enhanced CT (CECT), and MATERIAL AND

methodsThirty consecutive patients with HCC treated with TARE were included. Intraprocedural dual-phase CBCT acquisition protocol was developed to distinguish tumor volume in the early arterial phase and perfused volume of non-affected liver in the late arterial phase. Volumetric data obtained from pre-treatment CECT, dual-phase CBCT and [

resultsCBCT resulted as the most accurate method in predicting tumor- (R

conclusionOur study shows that dual-phase CBCT acquisition is a novel alternative method for correctly and safely administering more accurate and defined doses during TARE. CLINICALTRIALS: gov ID: NCT03981497.

Indexed as

Carcinoma, HepatocellularCone-Beam Computed TomographyEmbolization, TherapeuticLiver NeoplasmsPositron Emission Tomography Computed TomographySingle Photon Emission Computed Tomography Computed TomographyYttrium RadioisotopesAgedContrast MediaFemaleHumansMaleMiddle AgedRadiometryRadiopharmaceuticalsTechnetium Tc 99m Aggregated AlbuminContrast MediaRadiopharmaceuticalsTechnetium Tc 99m Aggregated AlbuminYttrium-90Yttrium RadioisotopesCone-beam computed tomography (CBCT)Hepatocellular carcinoma (HCC)Personalized dosimetryTransarterial embolization (TARE)

Identifiers

PMID39707126
PMCPMC12008061

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.