Evidence map›Paper›PMID 39707114›Full record

ArticleJournal of imaging informatics in medicine2025

Development and Validation of a Modality-Invariant 3D Swin U-Net Transformer for Liver and Spleen Segmentation on Multi-Site Clinical Bi-parametric MR Images.

Huixian Zhang, Hailong Li, Redha Ali, Wei Jia, Wen Pan, Scott B Reeder, David Harris, William Masch, Anum Aslam, Krishna Shanbhogue and 3 more

Abstract readValidation StudyMulticenter Study
In one paragraph

Article in Journal of imaging informatics in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Huixian ZhangImaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Hailong LiImaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Redha AliImaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Wei JiaImaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Wen PanImaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Scott B ReederDepartment of Radiology, Medical Physics, Biomedical Engineering, Medicine, Emergency Medicine, University of Wisconsin, Madison, WI, USA.
David HarrisDepartment of Radiology, Medical Physics, Biomedical Engineering, Medicine, Emergency Medicine, University of Wisconsin, Madison, WI, USA.
William MaschDepartment of Radiology, Michigan Medicine, Ann Arbor, MI, USA.
Anum AslamDepartment of Radiology, Michigan Medicine, Ann Arbor, MI, USA.
Krishna ShanbhogueDepartment of Radiology, New York University, New York, NY, USA.
Nehal A ParikhNeurodevelopmental Disorders Prevention Center, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Jonathan R DillmanImaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Lili HeImaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. lili.he@cchmc.org.

Funding

Quantification of Liver Fibrosis with MRI and Deep LearningR01EB030582 · NIBIB · CINCINNATI CHILDRENS HOSP MED CTR · PI HE, LILI · 2021 to 2024
$2.5M
MRI and Deep Learning for Early Prediction of Neurodevelopmental Deficits in Very Preterm InfantsR01EB029944 · NIBIB · CINCINNATI CHILDRENS HOSP MED CTR · PI HE, LILI · 2020 to 2023
$2.1M
NIBIB NIH HHS R01 EB029944NIBIB NIH HHS R01-EB029944NIBIB NIH HHS R01 EB030582NIBIB NIH HHS R01-EB030582
6 · The paper itself

Abstract

To develop and validate a modality-invariant Swin U-Net Transformer (UNETR) deep learning model for liver and spleen segmentation on abdominal T1-weighted (T1w) or T2-weighted (T2w) MR images from multiple institutions for pediatric and adult patients with known or suspected chronic liver diseases. In this IRB-approved retrospective study, clinical abdominal axial T1w and T2w MR images from pediatric and adult patients were retrieved from four study sites, including Cincinnati Children's Hospital Medical Center (CCHMC), New York University (NYU), University of Wisconsin (UW) and University of Michigan / Michigan Medicine (UM). The whole liver and spleen were manually delineated as the ground truth masks. We developed a modality-invariant 3D Swin UNETR using a modality-invariant training strategy, in which each patient's T1w and T2w MR images were treated as separate training samples. We conducted both internal and external validation experiments. A total of 241 T1w and 339 T2w MR sequences from 304 patients (age [mean

Indexed as

Deep LearningImage Interpretation, Computer-AssistedImaging, Three-DimensionalLiverLiver DiseasesMagnetic Resonance ImagingSpleenAdolescentAdultChildChild, PreschoolFemaleHumansMaleMiddle AgedRetrospective StudiesDeep learningMedical image segmentationTransformer

Identifiers

PMID39707114
PMCPMC12572494

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.