Genetic correlation and mendelian randomization reveal the impact of sleep traits on urolithiasis risk.

Mo Yan, Zhe-Xin Zhang, Jia-Xin Hu, Kai-Bin Wang, Cheng-Yi Liu

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Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Mo Yan *Department of Urology, Lu'an People's Hospital of Anhui Province, Lu'an Hospital of Anhui Medical University, Lu'an, China.

Zhe-Xin Zhang *Department of Urology, Xiangya Hospital, Central South University, Changsha, China.

Jia-Xin HuDepartment of Nephrology, Wu Gang People's Hospital, Wu Gang, China.

Kai-Bin WangTianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.

Cheng-Yi LiuDepartment of Urology, Lu'an People's Hospital of Anhui Province, Lu'an Hospital of Anhui Medical University, Lu'an, China. liucy89@qq.com.

Funding

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6 · The paper itself

Abstract

Urolithiasis is a common and recurrent condition in the urological spectrum. Despite various proposed mechanisms, the causal relationship between sleep traits and the risk of urolithiasis remains unclear. We used publicly available genome-wide association study (GWAS) summary data from the UK Biobank and FinnGen to perform a two-sample Mendelian randomization (MR) analysis and genetic correlation analysis, evaluating the causal relationship and genetic correlation between sleep traits (chronotype, getting up in the morning, sleep duration, nap during the day, and insomnia) and urolithiasis (calculus of the kidney and ureter, and calculus of the lower urinary tract). Additionally, multivariable MR (MVMR) analysis adjusted for body mass index (BMI) and other sleep characteristics was conducted to assess the direct impact of sleep traits on the risk of urinary tract stones. The LD score regression (LDSC) analysis indicated a genetic correlation between insomnia and upper urinary tract stones (r

Indexed as

Genome-Wide Association StudyMendelian Randomization AnalysisSleepUrolithiasisFemaleGenetic Predisposition to DiseaseHumansMalePolymorphism, Single NucleotideRisk FactorsSleep Initiation and Maintenance DisordersLD score regression analysisMendelian randomization analysisSleep traitsUrolithiasis

Identifiers

PMID39706855

DOI10.1038/s41598-024-82031-4

PMCPMC11662003

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