Evidence map›Paper›PMID 39706330›Full record

ArticleContemporary clinical trials2025

Development of the Positive Outcomes through Supported Transition (POST) opioid preventive intervention for youth in the legal system: Study protocol for a sequential multiple assignment randomized trial.

Ahnalee M Brincks, Kevin P Haggerty, Alexandria Kolberg, Katie M Albertson, Carolyn A McCarty, Margaret R Kuklinski, Ted Ryle, Kym R Ahrens

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04901312 (Identifying an Effective and Cost Beneficial Approach to Preventing OUD in Justice-Involved Youth), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04901312 naunknown statusnot on this map

Identifying an Effective and Cost Beneficial Approach to Preventing OUD in Justice-Involved Youth

TypeinterventionalSponsorSeattle Children's HospitalRan2021 to 2024Enrolled215ConditionsSubstance Use Disorders, RecidivismArmsAdolescent Community Reinforcement Approach, Assertive Continuing Care, Trauma Affect Regulation Guide for Education and Therapy, Motivational Interviewing, Opioid Education Workbook
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ahnalee M BrincksDepartment of Human Development and Family Studies, Michigan State University, East Lansing, MI, USA. Electronic address: brincksa@msu.edu.
Kevin P HaggertySocial Development Research Group, School of Social Work, University of Washington, Seattle, WA, USA.
Alexandria KolbergSeattle Children's Hospital and Research Institute, Seattle, WA, USA.
Katie M AlbertsonSeattle Children's Hospital and Research Institute, Seattle, WA, USA.
Carolyn A McCartySeattle Children's Hospital and Research Institute, Seattle, WA, USA; Department of Pediatrics, University of Washington, Seattle, WA, USA.
Margaret R KuklinskiSocial Development Research Group, School of Social Work, University of Washington, Seattle, WA, USA.
Ted RyleWashington State Department of Children, Youth and Families, Olympia, WA, USA.
Kym R AhrensSeattle Children's Hospital and Research Institute, Seattle, WA, USA; Department of Pediatrics, University of Washington, Seattle, WA, USA.

Funding

Using SMART Design to Identify an Effective and Cost-Beneficial Approach to Preventing OUD in Justice-Involved YouthUH3DA050189 · NIDA · SEATTLE CHILDREN'S HOSPITAL · PI AHRENS, KYM R, HAGGERTY, KEVIN P · 2021 to 2023
$4.1M
Using SMART Design to Identify an Effective and Cost-Beneficial Approach to Preventing OUD in Justice-Involved YouthUG3DA050189 · NIDA · SEATTLE CHILDREN'S HOSPITAL · PI AHRENS, KYM R, HAGGERTY, KEVIN P · 2019 to 2020
$1.3M
Developing Methods to Estimate Mediation Effects in Adaptive InterventionsK01DA046516 · NIDA · MICHIGAN STATE UNIVERSITY · PI BRINCKS, AHNALEE M · 2019 to 2023
$572k
NIDA NIH HHS K01 DA046516NIDA NIH HHS UG3 DA050189NIDA NIH HHS UH3 DA050189
6 · The paper itself

Abstract

Adolescents and young adults in the legal system (AYALS) are at high risk for opioid use disorder (OUD). Effective, efficient interventions to prevent OUD that support youth as they transition to the community are needed. The Positive Outcomes through Supported Transition intervention trial is designed to identify the optimal intensity and sequence of behavioral skills and case management components for OUD prevention. This sequential, multiple assignment randomized trial addresses three research questions: 1.whether to begin with a high-intensity, broad-scope intervention (Enhanced Adolescent Community Reinforcement Approach; E-ACRA) or a lower intensity intervention (Assertive Community Support; ACS), 2. whether to continue with E-ACRA or step-down to ACS after release, and 3. whether to step-up to E-ACRA or continue ACS for youth reporting problematic substance use after release. Youth committed to state custody will be recruited prior to their release and randomized to E-ACRA or ACS. At five weeks post-release, E-ACRA participants will be re-randomized to E-ACRA or ACS. ACS participants reporting problematic substance use at five weeks will be re-randomized to E-ACRA or ACS. Primary analyses will test the effects of initial intervention (E-ACRA vs. ACS); secondary analyses will test the effects of second-stage interventions. Cost-effectiveness analysis will determine whether the additional resources deployed to E-ACRA are justified economically by the outcomes achieved. Prevention is critical for this population. High-intensity interventions can be burdensome for participants (and agencies) and costly to deliver. This study examines how best to sequence high and low intensity interventions to maximize beneficial outcomes for the most youth. This study's design was pre-registered with clinicaltrials.gov (NCT04901312).

Indexed as

Opioid-Related DisordersAdolescentCase ManagementFemaleHumansMaleRandomized Controlled Trials as TopicResearch DesignYoung AdultAdaptive interventionAdolescentsEmerging adultsJuvenile justicePrevention

Identifiers

PMID39706330
PMCPMC11788021

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.