Evidence map›Paper›PMID 39705860›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2025

Sleep spindle variation in patients with Parkinson's disease on first nights of sub-optimal deep brain stimulation.

Rig Das, Stephen V Gliske, Dulce Maroni, Miguel Situ-Kcomt, Leslie C West, Michael O Summers, Siqun Tang, Pavan A Vaswani, Casey H Halpern, John A Thompson and 2 more

Abstract read
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In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rig DasDepartment of Neurosurgery, University of Nebraska Medical Center, Omaha, NE, United States.
Stephen V GliskeDepartment of Neurosurgery, University of Nebraska Medical Center, Omaha, NE, United States. Electronic address: steve.gliske@unmc.edu.
Dulce MaroniDepartment of Neurosurgery, University of Nebraska Medical Center, Omaha, NE, United States.
Miguel Situ-KcomtDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, United States.
Leslie C WestDepartment of Neurology, University of California San Francisco, San Fransisco, CA, United States.
Michael O SummersNebraska Medicine Sleep Center, Division of Pulmonary, Critical Care & Sleep Medicine, Internal Medicine, University of Nebraska Medical Center, Omaha, NE, United States.
Siqun TangSleep Medicine Division, Department of Psychiatry and Behavioral Science, Stanford University, Standford, CA, United States.
Pavan A VaswaniParkinson's Disease Research, Education and Clinical Center, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, United States; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Pennsylvania Hospital, Philadelphia, PA, United States.
Casey H HalpernRichards Medical Research Laboratories, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, United States; Department of Surgery, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, United States.
John A ThompsonDepartment of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO, United States; Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Clete A KushidaSleep Medicine Division, Department of Psychiatry and Behavioral Science, Stanford University, Standford, CA, United States.
Aviva AboschDepartment of Neurosurgery, University of Nebraska Medical Center, Omaha, NE, United States.

Funding

Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease: An Investigation of STN LFP Biomarkers In Sleep Dysregulation and RepairUH3NS113769 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI ABOSCH, AVIVA, HALPERN, CASEY HARRISON · 2020 to 2025
$5.2M
NINDS NIH HHS UH3 NS113769
6 · The paper itself

Abstract

objectiveDeep brain stimulation (DBS) targeting the subthalamic nucleus (STN) is a common treatment for motor symptoms of Parkinson's disease but its influence on non-motor symptoms is less clear. Sleep spindles are known to be reduced in patients with Parkinson's disease, but the effect of STN DBS is unknown. The objective of our study was to address this knowledge gap.

methodPolysomnograms were recorded for three consecutive nights in 15 patients with advanced Parkinson's disease (11 male, 4 female; age: 53-75 years), including at least one night each of unilateral STN DBS stimulation ON and OFF. Stimulation ON was set to 70 % of clinical amplitude to mitigate sleep being altered via changing motor symptoms or due to patient awareness of stimulation. Sleep spindles were detected in electroencephalogram (EEG) data by two previously published, validated automated sleep spindle detection algorithms: Ferrarelli et al. (2007) and Martin et al. (2013).

resultsSleep spindle density was higher during stimulation ON than OFF nights in 11 of 12 subjects using either sleep spindle detection algorithm (p<=0.01, Wilcoxon rank sum). Stimulation ON versus OFF had no statistically significant effect on sleep spindle duration or amplitude.

conclusionOur analysis indicates that a single night of sub-optimal STN stimulation significantly increases sleep spindle density in Parkinson's disease patients. SIGNIFICANCE: These results further our understanding of how DBS impacts non-motor symptoms of Parkinson's disease.

Indexed as

Deep Brain StimulationParkinson DiseaseSleepSleep StagesAgedElectroencephalographyFemaleHumansMaleMiddle AgedPolysomnographySubthalamic NucleusDeep brain stimulationParkinson’s diseasePolysomnographySleep qualitySleep spindleSubthalamic nucleus

Identifiers

PMID39705860
PMCPMC13377651

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.