Evidence map›Paper›PMID 39705707›Full record

ArticleACS applied bio materials2025

Casting Skin Dressing Containing Extractions of the Organic Part of Marine Sponges for Wound Healing.

Amanda de Souza, Cintia C S Martignago, Lívia Assis, Fernanda Vieira Botelho Delpupo, Marcelo Assis, Karolyne S J Sousa, Lais Caroline Souza E Silva, Laura O Líbero, Flavia de Oliveira, Ana Claudia Muniz Renno

Abstract read
In one paragraph

Article in ACS applied bio materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Amanda de SouzaDepartment of Biosciences, Federal University of São Paulo (UNIFESP), Lab 342, 136 Silva Jardim Street, Santos, SP 11015020, Brazil.ORCID 0000-0001-6353-0824
Cintia C S MartignagoDepartment of Biosciences, Federal University of São Paulo (UNIFESP), Lab 342, 136 Silva Jardim Street, Santos, SP 11015020, Brazil.
Lívia AssisScientific Institute and Technological Department, University Brazil, São Paulo-Itaquera, SP 04021-001,Brazil.
Fernanda Vieira Botelho DelpupoDepartment of Biosciences, Federal University of São Paulo (UNIFESP), Lab 342, 136 Silva Jardim Street, Santos, SP 11015020, Brazil.
Marcelo AssisDepartment of Biosciences, Federal University of São Paulo (UNIFESP), Lab 342, 136 Silva Jardim Street, Santos, SP 11015020, Brazil.ORCID 0000-0003-0355-5565
Karolyne S J SousaDepartment of Biosciences, Federal University of São Paulo (UNIFESP), Lab 342, 136 Silva Jardim Street, Santos, SP 11015020, Brazil.
Lais Caroline Souza E SilvaDepartment of Biosciences, Federal University of São Paulo (UNIFESP), Lab 342, 136 Silva Jardim Street, Santos, SP 11015020, Brazil.
Laura O LíberoCDMF - Department of Chemistry, Federal University of São Carlos (UFSCar), Washington Luís Road, São Carlos, SP 13565-905, Brazil.
Flavia de OliveiraDepartment of Biosciences, Federal University of São Paulo (UNIFESP), Lab 342, 136 Silva Jardim Street, Santos, SP 11015020, Brazil.
Ana Claudia Muniz RennoDepartment of Biosciences, Federal University of São Paulo (UNIFESP), Lab 342, 136 Silva Jardim Street, Santos, SP 11015020, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skin wounds are extremely frequent injuries related to many etiologies. They are a burden on healthcare systems worldwide. Skin dressings are the most popular therapy, and collagen is the most commonly used biomaterial, although new sources of collagen have been studied, especially spongin-like from marine sponges (SPG), as a promising source due to a similar composition to vertebrates and the ability to function as a cell-matrix adhesion framework. Despite evidence showing the positive effects of SPG for tissue healing, the effects of skin dressings manufactured are still limited. In this context, this study aimed at investigating the effects of collagen skin dressings in an experimental model of skin wounds in rats. For this purpose, SEM, FTIR, cell viability, morphological and morphometric aspects, collagen deposition, and immunostaining of TGF-β and FGF were evaluated. The results demonstrated micro- and macropores on the rough surface, peak characteristics of collagen, and no cytotoxicity for the skin dressing. Also, the control group (CG) after 5 and 10 days exhibited an intense inflammatory process and the presence of granulation tissue, while the treated group (TG) exhibited re-epithelialization after 10 days. The evaluation of granulation tissue and neoepithelial length had an intragroup statistical difference (

Indexed as

BandagesBiocompatible MaterialsPoriferaWound HealingAnimalsCell SurvivalCollagenHumansMaleMaterials TestingRatsRats, WistarSkinSurface PropertiesBiocompatible MaterialsCollagencasting methodChondrilla caribensischronic woundsspongin-like collagen

Identifiers

PMID39705707
PMCPMC11752525

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.