Evidence map›Paper›PMID 39705535›Full record

ArticleBlood advances2025

Fusion-specific chromatin profiles mediate transcriptional heterogeneity in MLL-rearranged acute lymphoblastic leukemia.

Shan Lin, Michael Kotliar, Sushmitha Vallabh, Anetta Ptasinska, Salam A Assi, Mark Wunderlich, Constanze Bonifer, Artem Barski, James C Mulloy

Abstract read
In one paragraph

Article in Blood advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shan LinDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.ORCID 0000-0002-9699-0250
Michael KotliarDivision of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.ORCID 0000-0002-6486-3898
Sushmitha VallabhDivision of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.ORCID 0000-0002-7470-4903
Anetta PtasinskaInstitute of Cancer and Genomic Sciences, College of Medicine and Dentistry, University of Birmingham, Birmingham, United Kingdom.
Salam A AssiInstitute of Cancer and Genomic Sciences, College of Medicine and Dentistry, University of Birmingham, Birmingham, United Kingdom.ORCID 0000-0001-5634-1347
Mark WunderlichDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.ORCID 0000-0002-2166-5146
Constanze BoniferInstitute of Cancer and Genomic Sciences, College of Medicine and Dentistry, University of Birmingham, Birmingham, United Kingdom.ORCID 0000-0002-4267-0825
Artem BarskiDivision of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.ORCID 0000-0002-1861-5316
James C MulloyDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Funding

VITAMIN K DEFICIENCY IN CHOLESTATIC LIVER DISEASEM01RR008084 · NCRR · CINCINNATI CHILDRENS HOSP MED CTR · PI STRAUSS, ARNOLD W · 1994 to 2009
$20.6M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR026314 · NCRR · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E. · 2009 to 2011
$14.3M
Instructive role of MLL fusion proteins in lineage determination and leukemogenesisR01CA215504 · NCI · UNIVERSITY OF CHICAGO · PI MULLOY, JAMES C, THIRMAN, MICHAEL J · 2017 to 2021
$3.0M
Therapeutic insights through patient derived leukemia xenograftsR50CA211404 · NCI · CINCINNATI CHILDRENS HOSP MED CTR · PI Mark Wunderlich · 2016 to 2026
$1.9M
SciDAP: Scientific Data Analysis PlatformR42HG011219 · NHGRI · DATIRIUM, LLC · PI BARSKI, ARTEM, KARTASHOV, ANDREY · 2022 to 2023
$1.6M
NCI NIH HHS R01 CA215504NCI NIH HHS R50 CA211404NCRR NIH HHS M01 RR008084NCRR NIH HHS UL1 RR026314NHGRI NIH HHS R42 HG011219
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID39705535
PMCPMC11875166

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.