ArticleScience advances2024
Cancer mutations rewire the RNA methylation specificity of METTL3-METTL14.
Abstract read
In one paragraph
Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- The cellular landscape of druggable RNA-binding proteins.Nature reviews. Drug discovery · 2026Review
- WTAP Transcriptional Suppression by KLF9 Drives Osteoclastogenesis via MAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- RNA modifications in cancer: regulators of tumor evolution and therapeutic response.Molecular cancer · 2026Review
- mInsects · 2026Review
- piR-26681 suppresses ovarian cancer progression by enhancing METTL3/METTL14-mediated mCellular & molecular biology letters · 2026Article
- RNA modifications in cancer and their detection: a review.Japanese journal of clinical oncology · 2026Review
- Suppression of Glucosylceramide Synthase Reverses Drug Resistance in Cancer Cells Harboring Homozygous p53 Mutants.International journal of molecular sciences · 2026Article
- The bladder cancer mEMBO reports · 2026Article
- Single-nucleotide m⁶A mapping uncovers redundant YTHDF function in planarian progenitor fate selection.The EMBO journal · 2026Article
- NNature reviews. Cancer · 2026Review
- RNA modifications in cancer: from biological insights to therapeutic targets.Bioorganic & medicinal chemistry · 2026Review
- Diatom-Derived Biochemicals: An In-Depth Analysis of Polysaccharides, Extraction Methodologies, and Diverse Applications.Applied biochemistry and biotechnology · 2026Review
- Inhibition ofACS omega · 2025Article
- RBM15-MKL1 fusion protein promotes leukemia via m6A methylation and Wnt pathway activation.Blood · 2025Article
- Inhibition ofbioRxiv : the preprint server for biology · 2025Article
- SUPREM: an engineered non-site-specific m6A RNA methyltransferase with highly improved efficiency.Nucleic acids research · 2024Article
- Decoding the molecular symphony: interactions between the mNAR cancer · 2024Review
- Challenges to mapping and defining mRNA (New York, N.Y.) · 2024Article
- Mass Spectrometry-Based Proteomics for Assessing Epitranscriptomic Regulations.Mass spectrometry reviewsReview
Corrections and comments
- Update of
Authors and funding
16 authors.
Chi ZhangDepartment of Biochemistry, Department of Biophysics, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-9209-4934
Robyn L ScottDepartment of Biochemistry, Department of Biophysics, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0001-6450-4708
Luiza TunesDepartment of Biochemistry, Department of Biophysics, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Meng-Hsiung HsiehChildren's Research Institute, Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0001-9791-1318
Ping WangDepartment of Biochemistry, Department of Biophysics, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Ashwani KumarEugene McDermott Center for Human Growth and Development, Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Brijesh B KhadgiDepartment of Biochemistry, Department of Biophysics, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-6206-2552
Yen-Yu YangDepartment of Chemistry, University of California at Riverside, Riverside, CA 92521, USA.
Katelyn A Doxtader LacyDepartment of Biochemistry, Department of Biophysics, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Emily HerrellDepartment of Biochemistry, Department of Biophysics, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-4620-1778
Xunzhi ZhangEugene McDermott Center for Human Growth and Development, Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-3599-1751
Bret EversDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0001-5686-0315
Yinsheng WangDepartment of Chemistry, University of California at Riverside, Riverside, CA 92521, USA.ORCID 0000-0001-5565-283X
Chao XingEugene McDermott Center for Human Growth and Development, Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-1838-0502
Hao ZhuChildren's Research Institute, Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-8417-9698
Yunsun NamDepartment of Biochemistry, Department of Biophysics, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-7939-8626
Funding
Chemical Biology of DNA and RNA AlkylationR35ES031707 · NIEHS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Yinsheng Wang · 2020 to 2026
$6.1MMechanisms of Microprocessor Function and RegulationR01GM122960 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI NAM, YUNSUN · 2017 to 2025
$3.2MSmall molecules to target the RNA methyltransferase complex METTL3/METTL14R01CA258589 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI NAM, YUNSUN · 2022 to 2025
$1.7MNCI NIH HHS R01 CA258589NIEHS NIH HHS R35 ES031707NIGMS NIH HHS R01 GM122960
Abstract
Chemical modification of RNAs is important for posttranscriptional gene regulation. The METTL3-METTL14 complex generates most
Indexed as
MethyltransferasesNeoplasmsAdenosineAlkB Homolog 5, RNA DemethylaseAnimalsCell Line, TumorHumansMethylationMiceMice, TransgenicMutationRNA, MessengerRNA MethylationAdenosineAlkB Homolog 5, RNA DemethylaseMethyltransferasesMETTL14 protein, humanMETTL3 protein, humanN-methyladenosineRNA, Messenger
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.