Evidence map›Paper›PMID 39705315›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

SKA2 enhances stress-related glucocorticoid receptor signaling through FKBP4-FKBP5 interactions in neurons.

Jakob Hartmann, Claudia Klengel, Larissa J Dillmann, Erin E Hisey, Kathrin Hafner, Rammohan Shukla, Marina Soliva Estruch, Thomas Bajaj, Tim Ebert, Katharine G Mabbott and 12 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Investigational drugs in PTSD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Epigenetic Mechanisms of Suicidal Behavior Formation: A Review.Medical journal of the Islamic Republic of Iran · 2026
    Review
  9. The Interaction BetweenBrain sciences · 2025
    Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Jakob HartmannDepartment of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478.ORCID 0000-0002-1960-8177
Claudia KlengelDepartment of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478.
Larissa J DillmannDepartment of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478.ORCID 0000-0003-2014-8419
Erin E HiseyDepartment of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478.
Kathrin HafnerDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich 80804, Germany.
Rammohan ShuklaDepartment of Neuroscience, University of Wyoming, Laramie, WY 82071.
Marina Soliva EstruchDepartment of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478.
Thomas BajajDepartment of Psychiatry and Psychotherapy, Research Group Neurohomeostasis, University Hospital, Boon 53127, Germany.ORCID 0000-0001-6153-6608
Tim EbertDepartment of Psychiatry and Psychotherapy, Research Group Neurohomeostasis, University Hospital, Boon 53127, Germany.
Katharine G MabbottDepartment of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478.
Luise RostinDepartment of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478.
Alexandra PhilipsenDepartment of Psychiatry and Psychotherapy, University Hospital, Bonn 53127, Germany.
William A CarlezonDepartment of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478.
Barbara GisabellaDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216.ORCID 0000-0002-0072-790X
Robert E McCullumsmithDepartment of Neurosciences, University of Toledo, Toledo, OH 43614.
John M VergisDepartment of Neurosciences, University of Toledo, Toledo, OH 43614.
Torsten KlengelDepartment of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478.
Sabina BerrettaDepartment of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478.ORCID 0000-0002-4057-7766
Nikolaos P DaskalakisDepartment of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478.
Harry PantazopoulosDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216.ORCID 0000-0002-8905-8377
Nils C Gassen *Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich 80804, Germany.ORCID 0000-0002-4265-3398
Kerry J Ressler *Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478.

Funding

SPARED CenterP50MH115874 · NIMH · MCLEAN HOSPITAL · PI CARLEZON, WILLIAM A. · 2019 to 2023
$13.7M
Cell Type Specific Genomic and Functional Dissection of Fear-Off Amygdala PathwaysR01MH108665 · NIMH · MCLEAN HOSPITAL · PI BOLSHAKOV, VADIM, RESSLER, KERRY J. · 2016 to 2025
$7.5M
Site 3/3, Understanding PTSD through Postmortem Targeted Brain MultiomicsR01MH117292 · NIMH · MCLEAN HOSPITAL · PI Nikolaos Daskalakis, KERRY J. RESSLER · 2018 to 2026
$5.0M
HHS | NIH | National Institute of Mental Health (NIMH) P50-MH115874HHS | NIH | National Institute of Mental Health (NIMH) R01-MH108665NIMH NIH HHS P50 MH115874NIMH NIH HHS R01 MH108665NIMH NIH HHS R01 MH117292
6 · The paper itself

Abstract

Genes involved in regulating the hypothalamic-pituitary-adrenal (HPA) axis, including the glucocorticoid receptor (GR), are linked to various stress-related psychopathologies including bipolar disorder as well as other mood and trauma-related disorders. The protein product of the cell cycle gene,

Indexed as

Chromosomal Proteins, Non-HistoneHypothalamo-Hypophyseal SystemNeuronsPituitary-Adrenal SystemReceptors, GlucocorticoidSignal TransductionTacrolimus Binding ProteinsAmygdalaAnimalsHippocampusHumansMaleMiceParaventricular Hypothalamic NucleusTacrolimus Binding Protein 5Chromosomal Proteins, Non-HistoneReceptors, GlucocorticoidSKA2 protein, humantacrolimus binding protein 4Tacrolimus Binding Protein 5Tacrolimus Binding Proteinsbipolar disorderglucocorticoid receptorhippocampusHPA axisstress

Identifiers

PMID39705315
PMCPMC11670087

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.