Evidence map›Paper›PMID 39705313›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Docetaxel response in BRCA1,p53-deficient mammary tumor cells is affected by Huntingtin and BAP1.

Martín González-Fernández, Carmen Perry, Nora Merete Gerhards, Paola Francica, Sven Rottenberg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. PMEnvironment & health (Washington, D.C.) · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Martín González-FernándezDepartment of Infectious Diseases and Pathobiology, Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland.ORCID 0009-0006-8308-5493
Carmen PerryDepartment of Infectious Diseases and Pathobiology, Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland.ORCID 0009-0007-9156-5603
Nora Merete GerhardsDepartment of Infectious Diseases and Pathobiology, Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland.
Paola FrancicaDepartment of Infectious Diseases and Pathobiology, Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland.
Sven RottenbergDepartment of Infectious Diseases and Pathobiology, Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland.ORCID 0000-0003-2044-9844

Funding

EC | European Research Council (ERC) ERC-2019-AdG-883877Krebsliga Schweiz (Swiss Cancer League) KFS-5519-02-2022Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (SNF) 310030_179360Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (SNF) 320030_219453
6 · The paper itself

Abstract

Taxanes are frequently used anticancer drugs known to kill tumor cells by inducing mitotic aberrations and segregation defects. A defining feature of specific cancers, notably triple-negative breast cancer (TNBC) and particularly those deficient in BRCA1, is chromosomal instability (CIN). Here, we focused on understanding the mechanisms of docetaxel-induced cytotoxicity, especially in the context of BRCA1-deficient TNBC. Using functional genetic screens in CIN+ cells, we identified genes that mediate docetaxel response and found an interaction between Huntingtin (HTT) and BRCA1-associated protein-1 (BAP1). We employed

Indexed as

BRCA1 ProteinDocetaxelHuntingtin ProteinTriple Negative Breast NeoplasmsTumor Suppressor Protein p53Tumor Suppressor ProteinsUbiquitin ThiolesteraseAnimalsAntineoplastic AgentsCell Line, TumorChromosomal InstabilityFemaleHumansMiceSpindle ApparatusAntineoplastic AgentsBAP1 protein, humanBAP1 protein, mouseBRCA1 ProteinBRCA1 protein, humanBrca1 protein, mouseDocetaxelHTT protein, humanHtt protein, mouseHuntingtin ProteinTumor Suppressor Protein p53Tumor Suppressor ProteinsUbiquitin ThiolesteraseBRCA1chromosomal instabilityHuntingtintaxanestriple negative breast cancer

Identifiers

PMID39705313
PMCPMC11670238

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.