Evidence map›Paper›PMID 39705191›Full record

ArticleGlia2025

WDR49-Positive Astrocytes Mark Severity of Neurodegeneration in Frontotemporal Lobar Degeneration and Alzheimer's Disease.

Ana Rajicic, Lucia A A Giannini, Emma Gerrits, Renee van Buuren, Shamiram Melhem, Johan A Slotman, Annemieke J M Rozemuller, Bart J L Eggen, John C van Swieten, Harro Seelaar

Abstract read
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In one paragraph

Article in Glia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ana RajicicDepartment of Neurology and Alzheimer Centre Erasmus MC, Erasmus MC University Medical Center, Rotterdam, the Netherlands.ORCID 0009-0003-6399-8170
Lucia A A GianniniDepartment of Neurology and Alzheimer Centre Erasmus MC, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Emma GerritsDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Renee van BuurenDepartment of Neurology and Alzheimer Centre Erasmus MC, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Shamiram MelhemDepartment of Neurology and Alzheimer Centre Erasmus MC, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Johan A SlotmanDepartment of Pathology and Erasmus Optical Imaging Center, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Annemieke J M RozemullerDepartment of Pathology, Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Bart J L EggenDepartment of Biomedical Sciences of Cells & Systems, Section of Molecular Neurobiology, University of Groningen and University Medical Center Groningen, Groningen, Netherlands.ORCID 0000-0001-8941-0353
John C van SwietenDepartment of Neurology and Alzheimer Centre Erasmus MC, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Harro SeelaarDepartment of Neurology and Alzheimer Centre Erasmus MC, Erasmus MC University Medical Center, Rotterdam, the Netherlands.

Funding

Alzheimer NederlandBluefield Project to Cure Frontotemporal DementiaThe Netherlands Organization for Health Research and Development 733050103The Netherlands Organization for Health Research and Development 733050513
6 · The paper itself

Abstract

A subpopulation of astrocytes expressing WD Repeat Domain 49 (WDR49) was recently identified in frontotemporal lobar degeneration (FTLD) with GRN pathogenic variants. This is the first study to investigate their expression and relation to pathology in other FTLD subtypes and Alzheimer's disease (AD). In a postmortem cohort of TDP-43 proteinopathies (12 GRN, 11 C9orf72, 9 sporadic TDP-43), tauopathies (13 MAPT, 8 sporadic tau), 10 AD, and four controls, immunohistochemistry and immunofluorescence were performed for WDR49 and pathological inclusions on frontal, temporal, and occipital cortical sections. WDR49-positive cell counts (adjusted per mm

Indexed as

Alzheimer DiseaseAstrocytesBrainFrontotemporal Lobar DegenerationAgedAged, 80 and overDNA-Binding ProteinsFemaleHumansMaleMiddle Agedtau ProteinsDNA-Binding Proteinstau ProteinsAlzheimer's diseaseastrocytesfrontotemporal lobar degenerationWDR49

Identifiers

PMID39705191
PMCPMC11920684

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.