Evidence map›Paper›PMID 39705018›Full record

ArticleACS infectious diseases2025

Identification of Cysteine Metabolism Regulator (CymR)-Derived Pentapeptides as Nanomolar Inhibitors of

Jordan L Pederick, Bethiney C Vandborg, Amir George, Hannah Bovermann, Jeffrey M Boyd, Joel S Freundlich, John B Bruning

Abstract read
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Jordan L PederickInstitute for Photonics and Advanced Sensing (IPAS), School of Biological Sciences, The University of Adelaide, Adelaide, South Australia 5005, Australia.ORCID 0000-0003-4048-9771
Bethiney C VandborgInstitute for Photonics and Advanced Sensing (IPAS), School of Biological Sciences, The University of Adelaide, Adelaide, South Australia 5005, Australia.ORCID 0000-0002-3234-3089
Amir GeorgeDepartment of Pharmacology, Physiology, and Neuroscience, Rutgers University-New Jersey Medical School, Newark, New Jersey 07101, United States.
Hannah BovermannDepartment of Biochemistry and Microbiology, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, United States.
Jeffrey M BoydDepartment of Biochemistry and Microbiology, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, United States.ORCID 0000-0001-7721-3926
Joel S FreundlichDepartment of Pharmacology, Physiology, and Neuroscience, Rutgers University-New Jersey Medical School, Newark, New Jersey 07101, United States.ORCID 0000-0002-3411-3455
John B BruningInstitute for Photonics and Advanced Sensing (IPAS), School of Biological Sciences, The University of Adelaide, Adelaide, South Australia 5005, Australia.ORCID 0000-0002-6919-1824

Funding

Therapeutics for drug resistant-bacteria: Arylpropionyl-phloroglucinolsU19AI109713 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI DARTOIS, VERONIQUE · 2014 to 2018
$26.9M
Mechanisms of cellular respiration-dependent cell lysis and its impact on biofilm formation and disassembly in Staphylococcus aureus.R01AI139100 · NIAID · RUTGERS, THE STATE UNIV OF N.J. · PI BOYD, JEFF M · 2018 to 2022
$1.9M
NIAID NIH HHS R01 AI139100NIAID NIH HHS U19 AI109713
6 · The paper itself

Abstract

The pathway of bacterial cysteine biosynthesis is gaining traction for the development of antibiotic adjuvants. Bacterial cysteine biosynthesis is generally facilitated by two enzymes possessing

Indexed as

Bacterial ProteinsCysteineCysteine SynthaseStaphylococcus aureusAnti-Bacterial AgentsCrystallography, X-RayEnzyme InhibitorsModels, MolecularAnti-Bacterial AgentsBacterial ProteinsCysteineCysteine SynthaseEnzyme Inhibitorscysteine biosynthesiscysteine synthaseenzyme inhibitionpeptide inhibitorsulfur assimilation

Identifiers

PMID39705018
PMCPMC12176409

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.