Evidence map›Paper›PMID 39704923›Full record

ArticleJournal of pharmacokinetics and pharmacodynamics2024

Translational pharmacokinetic and pharmacodynamic modelling of the anti-ADAMTS-5 NANOBODY

Joao N S Pereira, Ingrid Ottevaere, Benedikte Serruys, Hans Guehring, Christoph Ladel, Sven Lindemann

Abstract read
In one paragraph

Article in Journal of pharmacokinetics and pharmacodynamics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joao N S Pereira *The Healthcare Business of Merck KGaA, Frankfurter Str. 250, 64293, Darmstadt, Germany. joao.ns.pereira@merckgroup.com.ORCID 0000-0001-7395-9392
Ingrid Ottevaere *Sanofi Ghent, Technologiepark 21, Zwijnaarde, B-9052, Belgium.
Benedikte SerruysSanofi Ghent, Technologiepark 21, Zwijnaarde, B-9052, Belgium.
Hans GuehringThe Healthcare Business of Merck KGaA, Frankfurter Str. 250, 64293, Darmstadt, Germany.
Christoph LadelThe Healthcare Business of Merck KGaA, Frankfurter Str. 250, 64293, Darmstadt, Germany.
Sven LindemannThe Healthcare Business of Merck KGaA, Frankfurter Str. 250, 64293, Darmstadt, Germany. sven.lindemann@merckgroup.com.ORCID 0000-0002-0885-6175

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

M6495 is a first-in-class NANOBODY

Indexed as

ADAMTS5 ProteinBiomarkersEpitopesMacaca fascicularisSingle-Domain AntibodiesAnimalsDose-Response Relationship, DrugFemaleHumansMaleModels, BiologicalADAMTS5 ProteinBiomarkersEpitopesSingle-Domain AntibodiesADAMTS-5AggrecanARGSM6495NanobodyOsteoarthritisPharmacokinetics

Identifiers

PMID39704923
PMCPMC11662058

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.