ArticleBiomechanics and modeling in mechanobiology2025
Full-field, frequency-domain comparison of simulated and measured human brain deformation.
Article in Biomechanics and modeling in mechanobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- A novel spatiotemporal decomposition and identification of sparse equations for human brain deformation.Scientific reports · 2026Article
- Multimodal characterization of intracranial biomechanics in a 3D biofidelic head surrogate.Journal of the mechanical behavior of biomedical materials · 2026Article
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6 authors.
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Abstract
We propose a robust framework for quantitatively comparing model-predicted and experimentally measured strain fields in the human brain during harmonic skull motion. Traumatic brain injuries (TBIs) are typically caused by skull impact or acceleration, but how skull motion leads to brain deformation and consequent neural injury remains unclear and comparison of model predictions to experimental data remains limited. Magnetic resonance elastography (MRE) provides high-resolution, full-field measurements of dynamic brain deformation induced by harmonic skull motion. In the proposed framework, full-field strain measurements from human brain MRE in vivo are compared to simulated strain fields from models with similar harmonic loading. To enable comparison, the model geometry and subject anatomy, and subsequently, the predicted and measured strain fields are nonlinearly registered to the same standard brain atlas. Strain field correlations (
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