Evidence map›Paper›PMID 39704859›Full record

ArticleJournal of molecular histology2024

Differential effects of liraglutide naltrexone/bupropion, and caloric restriction on metabolic parameters and beta-cell regeneration in type 2 diabetic rat model: role of beta arrestin 1.

Dina H Merzeban, Amani M El Amin Ali, Reem O Hammad, Mohamed H Elmahdi, Marwa A Sofi, Rania H Mahmoud, Sayed M Metwally, Ahmed M El Ebiary

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Article in Journal of molecular histology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dina H MerzebanThe Departments of Medical Physiology, Faculty of Medicine, Fayoum University, Fayoum, Egypt. dhm00@fayoum.edu.eg.
Amani M El Amin AliThe Departments of Medical Physiology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Reem O HammadThe Departments of Medical Physiology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Mohamed H ElmahdiThe Departments of Anatomical Pathology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Marwa A SofiThe Departments of Histology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Rania H MahmoudThe Departments of Biochemistry and Molecular Biology, Fayoum University, Fayoum, Egypt.
Sayed M MetwallyThe Departments of Pharmacology and Toxicology, Faculty of Pharmacy, Fayoum University, Fayoum, Egypt.
Ahmed M El EbiaryThe Departments of Medical Physiology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traditional antidiabetic treatments often carry the risk of beta-cell exhaustion, highlighting the need for therapies that promote beta-cell regeneration. This study investigates the comparative effects of Liraglutide, naltrexone/bupropion (NTX + BUP), and caloric restriction on metabolic control and beta-cell regeneration in a rat model of obese type 2 diabetes. Fifty male albino rats were randomized into five groups: normal control, diabetic control, diabetic + caloric restriction (50%), diabetic + NTX + BUP (4 mg/45 mg /kg/day orally), and diabetic + liraglutide (0.3 mg/kg/day, S.C). Body weight, BMI, serum glucose, insulin, lipid profile, atherogenic indices, beta-arrestin-1 levels, pancreatic histopathology, and immunohistochemical staining for insulin and Ki67 were assessed. All interventions significantly improved body weight, BMI, glycemic control, lipid profiles (except HDL), and atherogenic indices compared to the diabetic control group. NTX + BUP and caloric restriction resulted in greater weight loss compared to liraglutide. Of note, liraglutide significantly decreased β-arrestin-1 levels compared to both NTX + BUP and caloric restriction. Furthermore, liraglutide and caloric restriction significantly increased anti-insulin antibodies and Ki67 indicating beta-cell regeneration, while NTX + BUP showed insignificant effects. Thus we can conclude that, while NTX + BUP demonstrates efficacy in improving metabolic parameters in obese type 2 diabetic rats, it shows limitations in promoting beta-cell regeneration compared to liraglutide and caloric restriction.

Indexed as

beta-Arrestin 1BupropionCaloric RestrictionDiabetes Mellitus, Type 2Insulin-Secreting CellsLiraglutideNaltrexoneAnimalsBlood GlucoseBody WeightDiabetes Mellitus, ExperimentalDisease Models, AnimalHypoglycemic AgentsInsulinMaleRatsbeta-Arrestin 1Blood GlucoseBupropionHypoglycemic AgentsInsulinLiraglutideNaltrexoneCaloric restrictionLiraglutideNaltrexone/bupropionType 2 diabetesβ-cell regeneration

Identifiers

PMID39704859

What OpenQuestion holds

Texttitle and abstract
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.