Evidence map›Paper›PMID 39704822›Full record

Trial reportPsychopharmacology2025

Alcohol increases social engagement in dyadic interactions: role of partner's drug state.

Hanna Molla, Tyler O'Neill, Evan Hahn, Royce Lee, Harriet de Wit

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Psychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hanna MollaDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, 5841 S Maryland Ave MC3077, Chicago, IL, 60615, USA.
Tyler O'NeillDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, 5841 S Maryland Ave MC3077, Chicago, IL, 60615, USA.
Evan HahnDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, 5841 S Maryland Ave MC3077, Chicago, IL, 60615, USA.
Royce LeeDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, 5841 S Maryland Ave MC3077, Chicago, IL, 60615, USA.
Harriet de WitDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, 5841 S Maryland Ave MC3077, Chicago, IL, 60615, USA. hdew@uchicago.edu.ORCID https://orcid.org/0000-0002-7211-8994

Funding

National Institute of Health DA02812
6 · The paper itself

Abstract

rationaleAlcohol is commonly used in social environments and is known to facilitate social behaviors. However, most controlled laboratory studies on alcohol have been conducted in isolated settings, limiting our understanding of its effects on social interactions.

objectivesThe current study was designed to examine the effects of alcohol on dyadic interactions in healthy volunteers (N = 37), with a focus on the influence of the conversation partner's drug state.

methodsUsing a 4-session, placebo-controlled, within-subjects design, participants received a moderate dose of alcohol (0.8 g/kg men) or placebo in randomized order before engaging in a 45-minute semi-structured conversation with a partner who received either alcohol or placebo. Partners were always strangers. Outcome measures included subjective responses to alcohol, self-reported closeness to partners, and facial expressions during interactions analyzed via a machine learning model.

resultsAlcohol produced its expected subjective effects, some of which were enhanced when the partner also received alcohol. Alcohol enhanced enjoyment of social interactions and feelings of connectedness, irrespective of the partner's drug condition. Facial expression analysis revealed that alcohol increased positive and decreased negative emotional expressions. For women but not men, these effects were more pronounced when their conversation partners also received alcohol. Individual emotion analysis revealed that alcohol increased the intensity of facial expressions associated with amusement, joy, and excitement, while reducing emotions such as awkwardness and contempt.

conclusionsOur findings show that alcohol increases feelings of social connectedness, and that responses to alcohol can be influenced by the drug state of interacting partners. The increased feelings of social connection may contribute to risk for escalation of use.

Indexed as

Alcohol DrinkingEthanolInterpersonal RelationsSocial InteractionAdultEmotionsFacial ExpressionFemaleHumansMaleSocial BehaviorYoung AdultEthanolAlcoholEmotionInteractionSocial

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.