Evidence map›Paper›PMID 39704798›Full record

ArticleNeuroradiology2025

Black Bone MRI vs. CT in temporal bone assessment in craniosynostosis: a radiation-free alternative.

Silvia Valeggia, Marjolein H G Dremmen, Irene M J Mathijssen, Linda Gaillard, Renzo Manara, Riccardo Ceccato, Martijn van Hattem, Renske Gahrmann

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Cranial nerves involvement in craniosynostosis: a systematic review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
    Pooled it
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Silvia ValeggiaNeuroradiology, Department of Neurosciences, University of Padova, Via Belzoni, 160, 35121, Padova, Italy. silvia.valeggia@unipd.it.ORCID http://orcid.org/0000-0001-9722-7145
Marjolein H G DremmenDepartment of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-5278-1369
Irene M J MathijssenDepartment of Plastic and Reconstructive Surgery and Hand Surgery, Erasmus MC, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-1675-9922
Linda GaillardDepartment of Plastic and Reconstructive Surgery and Hand Surgery, Erasmus MC, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-7982-6248
Renzo ManaraNeuroradiology, Department of Neurosciences, University of Padova, Via Belzoni, 160, 35121, Padova, Italy.ORCID http://orcid.org/0000-0002-5130-3971
Riccardo CeccatoDepartment of Management and Engineering (DTG), University of Padova, Stradella S. Nicola, 3, 36100, Vicenza, Italy.ORCID http://orcid.org/0000-0002-8629-8439
Martijn van HattemDepartment of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.
Renske GahrmannDepartment of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0001-7384-8633

Funding

Horizon 2020 Framework Programme EJP RD COFUND-EJP N° 825575
6 · The paper itself

Abstract

background and purposeCraniosynostoses are rare congenital craniofacial malformations, variably affected by hearing loss, often requiring repeated CT examinations to assess skull or temporal bone (TB) abnormalities. In order to avoid radiation exposure in these young patients, efforts are made to assess the skull abnormalities on MR bone imaging sequences, such as Black Bone (BB). Our aim is to compare BB, a radiation-free imaging technique, with CT for the assessment of the TB. MATERIALS AND

methods48 patients who underwent both BB and CT (2016-2021) in Sophia Children's Hospital, Erasmus MC, Rotterdam, were retrospectively investigated. BB and CT (the diagnostic gold standard for imaging the temporal bone) were evaluated blindly and independently by 3 observers; visibility and abnormalities of TB structures and cranial nerves were scored; abnormal findings were confirmed by a senior pediatric neuroradiologist. The statistical analysis was performed using Gwet's AC1 agreement and modified versions of the Wilcoxon signed-rank test and sign test with a Bonferroni-Holm correction (p < 0.05).

resultsCT was rated higher than BB in structure visibility (global p = 0.0002), but was rated similar to BB when assessing TB anatomy and pathology (global p = 0.58). The visibility ratings showed better interobserver agreement values on CT than BB. In the normal/abnormal ratings, both BB (0.75-1) and CT (0.88-1) showed high interobserver agreement values.

conclusionOur preliminary results suggest that BB is a promising tool for screening TB pathology in patients with craniosynostosis who require MR imaging.

Indexed as

CraniosynostosesMagnetic Resonance ImagingTemporal BoneTomography, X-Ray ComputedChildChild, PreschoolFemaleHumansInfantMaleRetrospective StudiesBlack boneCraniosynostosisMRITemporal bone

Identifiers

PMID39704798

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.