Evidence map›Paper›PMID 39704665›Full record

ArticleEnvironmental science & technology2025

Bioactivity Profiling of Chemical Mixtures for Hazard Characterization.

Xiaojing Li, Jiarui Zhou, Yaohui Bai, Meng Qiao, Wei Xiong, Tobias Schulze, Martin Krauss, Timothy D Williams, Ben Brown, Luisa Orsini and 2 more

Abstract read
In one paragraph

Article in Environmental science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Planetary Boundary for Novel Entities: Time for a Reboot.Environmental science & technology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaojing LiCentre for Environmental Research and Justice (CERJ), School of Biosciences, The University of Birmingham, Birmingham B15 2TT, U.K.ORCID 0000-0002-2796-5342
Jiarui ZhouCentre for Environmental Research and Justice (CERJ), School of Biosciences, The University of Birmingham, Birmingham B15 2TT, U.K.ORCID 0000-0002-1025-718X
Yaohui BaiResearch Centre for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, P. R. China.ORCID 0000-0002-2086-4477
Meng QiaoResearch Centre for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, P. R. China.
Wei XiongKey Laboratory of Environmental Biotechnology, Research Centre for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, P. R. China.
Tobias SchulzeDepartment Exposure Science, Helmholtz Centre for Environmental Research - UFZ, 04318 Leipzig, Germany.
Martin KraussDepartment Exposure Science, Helmholtz Centre for Environmental Research - UFZ, 04318 Leipzig, Germany.ORCID 0000-0002-0362-4244
Timothy D WilliamsCentre for Environmental Research and Justice (CERJ), School of Biosciences, The University of Birmingham, Birmingham B15 2TT, U.K.
Ben BrownEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley 94720, United States.
Luisa OrsiniCentre for Environmental Research and Justice (CERJ), School of Biosciences, The University of Birmingham, Birmingham B15 2TT, U.K.
Liang-Hong GuoHangzhou Institute for Advanced Study, UCAS, Hangzhou, Zhejiang 310020, P. R. China.ORCID 0000-0003-1399-5716
John K ColbourneCentre for Environmental Research and Justice (CERJ), School of Biosciences, The University of Birmingham, Birmingham B15 2TT, U.K.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The assessment and regulation of chemical toxicity to protect human health and the environment are done one chemical at a time and seldom at environmentally relevant concentrations. However, chemicals are found in the environment as mixtures, and their toxicity is largely unknown. Understanding the hazard posed by chemicals within the mixture is critical to enforce protective measures. Here, we demonstrate the application of bioactivity profiling of environmental water samples using the sentinel and ecotoxicology model species

Indexed as

Water Pollutants, ChemicalAnimalsDaphniaRiversWater Pollutants, Chemicalbiomolecular effect datachemical mixturesfreshwaternew approach methodologies (NAMs)transcriptomics

Identifiers

PMID39704665
PMCPMC11741114

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.