ArticleEuropean endodontic journal2024
Radiomic Parameters in Periapical Lesions: A CBCT Analysis Evaluating Volumetric Size, Cortical Expansion, Erosion, and Shape.
Article in European endodontic journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Comparative assessment of CBCT and digital radiography in quantifying periapical pathology (in vitro study).BMC oral health · 2026Article
- Enhancing the preoperative differentiation of ameloblastoma and odontogenic keratocyst using pathomics-guided radiomics: a pilot study.BMC oral health · 2026Article
- Radiomics-Based Differential Diagnosis of Radicular Cysts and Apical Granulomas on CBCT Images Using RadC-CNN Architecture.Diagnostics (Basel, Switzerland) · 2026Article
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5 authors.
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Abstract
objectiveTo investigate significant differences in selected radiomic parameters when classifying periapical lesions based on volumetric size, cortical expansion, erosion, and shape using Cone Beam Computed Tomography (CBCT).
methodsA retrospective analytical and comparative study was conducted on 100 small field of view (FOV) 50×50 mm CBCT scans collected between the years 2018 and 2023. The study involved qualitative classification of periapical lesions, followed by segmentation and extraction of radiomic parameters. The extracted parameters included first-order features such as energy, entropy, total energy, and uniformity; texture features like grey-level co-occurrence matrix contrast (GLCMC) and neighbouring grey tone difference matrix contrast (NGTDMC); and shape features including elongation, flatness, sphericity, and mesh volume, utilising 3D Slicer and Pyradiomics. The normal distribution of the variables was determined using the Shapiro-Wilk test. Various tests were used to assess significant differences, including Student's t-test, Mann-Whitney U test, ANOVA, and Tukey's post hoc analysis.
resultsSignificant differences were observed in the following parameters among the classification levels when classifying periapical lesions according to their volumetric size. There were significant differences in energy with a p-value of 0.001 and total energy with a p-value of 0.02. NGTDMC also showed a significant difference with a p-value of 0.001. A larger volumetric size is associated with greater energy and lower contrast. Significant differences in periapical lesions with erosion were found in shape sphericity (mean 0.34, SD 0.10, p=0.01), energy (mean 3.73×10¹⁰, SD 4.52×10¹⁰, p=0.002), and NGTDMC (mean 0.05, SD 0.02, p=0.001) compared to lesions without erosion. GLCMC was lower in erosive lesions (mean 18.94, SD 6.81, p=0.03) than in non-erosive ones (mean 22.28, SD 8.48). Regular-shaped periapical lesions demonstrated significantly greater elongation (mean 0.794, SD 0.115, p=0.006) and flatness (mean 0.614, SD 0.107, p=0.005) than irregular-shaped lesions. These findings suggest that regular-shaped periapical lesions are more elongated and flatter than irregular ones. No significant differences were found in radiomic features depending on the presence or absence of expansion in the periapical lesion.
conclusionThere are significant differences in texture and first-order radiomic features in periapical lesions classified based on size, erosion, and shape. This research's relevance lies in its potential to improve the quantitative characterisation of periapical lesions, leading to an objective interpretation. (EEJ-2023-11-159).
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