ArticleClinical practice and cases in emergency medicine2024
Immune Checkpoint Inhibitor-Induced Primary Adrenal Insufficiency: A Case Report.
Article in Clinical practice and cases in emergency medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Effects of immune checkpoint inhibitors on perioperative endocrine abnormalities and intraoperative hemodynamics in patients undergoing radical gastrectomy: a retrospective propensity score-matched cohort study.Journal of anesthesia · 2026Article
- Perioperative immunotherapy in resectable HNSCC: biological rationale to practical multidisciplinary implementation.Frontiers in oncology · 2026Review
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionOne of the less common and more life-threatening etiologies of adrenal insufficiency is immune checkpoint inhibitor (ICI)-induced primary adrenal insufficiency (PAI). Patients typically present with fatigue, malaise, and nausea and are treated empirically with hydrocortisone. CASE REPORT: We present the case of a 59-year-old female who presented with hypotension, which initially was thought to be due to hypovolemia or medication-related, but was ultimately found to have PAI.
conclusionThis case highlights the importance of early detection of ICI-induced primary adrenal insufficiency, given its associated morbidity and mortality and its incidence in patients with a history of immunotherapy.
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Registered trials
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