Evidence map›Paper›PMID 39704500›Full record

ArticlemBio2025

Mono-allelic epigenetic regulation of polycistronic transcription initiation by RNA polymerase II in

Rudo Kieft, Laura Cliffe, Haidong Yan, Robert J Schmitz, Stephen L Hajduk, Robert Sabatini

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Mapping Open Chromatin in Trypanosoma brucei Using ATAC-Seq.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Rudo KieftDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA.
Laura CliffeDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA.
Haidong YanDepartment of Genetics, University of Georgia, Athens, Georgia, USA.
Robert J SchmitzDepartment of Genetics, University of Georgia, Athens, Georgia, USA.
Stephen L HajdukDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA.
Robert SabatiniDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA.ORCID 0000-0002-0188-0201

Funding

Regulation of RNA polymerase II transcription in trypanosomatidsR01AI109108 · NIAID · UNIVERSITY OF GEORGIA · PI SABATINI, ROBERT S · 2014 to 2022
$3.7M
Trypanosome Lysis by Human Haptoglobin Related ProteinR01AI039033 · NIAID · UNIVERSITY OF GEORGIA · PI HAJDUK, STEPHEN L · 1996 to 2014
$3.5M
Lysis of Trypanosomes by Haptoglobin Related ProteinR21AI039033 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HAJDUK, STEPHEN L · 2001 to 2001
$287k
HHS | National Institutes of Health (NIH) AI39033HHS | National Institutes of Health (NIH) R01AI109108NIAID NIH HHS R01 AI039033NIAID NIH HHS R01 AI109108NIAID NIH HHS R21 AI039033
6 · The paper itself

Abstract

Unique for a eukaryote, protein-coding genes in trypanosomes are arranged in polycistronic transcription units (PTUs). This genome arrangement has led to a model where Pol II transcription of PTUs is unregulated and changes in gene expression are entirely post-transcriptional.

Indexed as

Epigenesis, GeneticRNA Polymerase IITranscription Initiation, GeneticTrypanosoma brucei bruceiAllelesPromoter Regions, GeneticProtozoan ProteinsTranscription, GeneticProtozoan ProteinsRNA Polymerase IIbase JHpHb receptorpolycistronic transcriptiontranscription initiationTrypanosoma bruceitrypanosome lytic factor

Identifiers

PMID39704500
PMCPMC11796357

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.