ArticleMovement disorders clinical practice2025
Gastrointestinal Dysfunction Bears on the Clinical-Biological Profile of Parkinson's Disease.
Article in Movement disorders clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Constipation Is Linked to Neuroinflammation in Early Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- CSF phospho-tau levels at Parkinson's disease onset predict the risk for development of motor complications.Journal of neurology · 2025Article
- Apolipoprotein E ε4-Specific Relationship Between Serum Olfactomedin 4 and Alzheimer's Disease.Molecular neurobiology · 2025Article
- Phosphorylated alpha-synuclein distribution in the colonic enteric nervous system of patients with diverticular disease.IBRO neuroscience reports · 2025Article
- The role of vagus nerve stimulation in modulating Parkinson's disease via the microbiota-gut-brain axis: a comprehensive review.Frontiers in neurology · 2025Review
- Aerobic exercise and gut flora: a key link to improved cognitive impairment in mice with Parkinson's disease.Frontiers in aging neuroscience · 2025Article
- Parkinson's disease physiopathology-beyond theFrontiers in aging neuroscience · 2025Review
- Correlation of systemic immune inflammation index and systemic inflammatory response index with the severity of Parkinson's disease.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundGastrointestinal dysfunction (GID) accompanies any phase of Parkinson's disease (PD), underlying differential clinical-pathological trajectories.
objectiveTo investigate associations between GID and peripheral immune or neurodegeneration-related markers in PD.
methodsOne-hundred-and-fourteen patients (n = 55 de novo, DN; n = 59 middle-advanced, MA) completed the Gastrointestinal Dysfunction Scale for PD (GIDS-PD), and other motor and non-motor scales; paired measurement of amyloid-β42, amyloid-β42β/β40, total-tau, phosphorylated-181-tau, total α-synuclein CSF levels, albumin ratio, and peripheral blood cell count were collected. Group and correlation analyses were performed.
resultsMA patients had greater GID than DN. GIDS-PD scores directly correlated with MDS-UPDRS-III and non-motor scores in both groups, although more in DN. GIDS-PD scores were directly associated with α-synuclein and inversely with lymphocytes only in DN; conversely, they were positively associated with tau proteins and albumin ratio, and negatively with amyloid-β-peptides in both groups.
conclusionsThe burden of GID increases along the PD course with associated stage-specific clinical-biological patterns.
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