Evidence map›Paper›PMID 39704257›Full record

ArticleNeurourology and urodynamics2025

Relationship of Sex and Diagnosis With Symptoms and Illness Impact in Urologic Chronic Pelvic Pain; A Mapp Network Analysis.

Bruce D Naliboff, Tara McWilliams, J Quentin Clemens, Michael A Pontari, Alisa J Stephens-Shields, Robert Moldwin, Siobhan Sutcliffe, Chris Mullins, J Richard Landis

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurourology and urodynamics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02514265 (MAPP Research Network), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02514265 completednot on this map

MAPP Research Network: Trans-MAPP Study of Urologic Chronic Pelvic Pain: Symptom Patterns Study (SPS)

TypeobservationalSponsorUniversity of PennsylvaniaRan2015 to 2020Enrolled640ConditionsInterstitial Cystitis, Chronic Prostatitis
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Interstitial Cystitis/Bladder Pain Syndrome in Men.Neurourology and urodynamics · 2026
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bruce D NaliboffDepartment of Medicine, University of California, Los Angeles, California, USA.
Tara McWilliamsPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
J Quentin ClemensUrology - Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Michael A PontariLewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.
Alisa J Stephens-ShieldsPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Robert MoldwinZucker School of Medicine, Hofstra-Northwell, Hempstead, New York, USA.
Siobhan SutcliffeWashington University School of Medicine, Washington University in St. Louis, St. Louis, Washington, USA.
Chris MullinsNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
J Richard LandisPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID http://orcid.org/0000-0001-8099-0988

Funding

MAPP Research NetworkU01DK082316 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI LANDIS, J RICHARD · 2008 to 2018
$17.2M
Role of CNS in Modulation of Pelvic Pain SyndromeU01DK082342 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KLUMPP, DAVID J · 2008 to 2021
$10.5M
Urology Chronic Pelvic Pain Longitudinal Symptom Patterns StudyU01DK082344 · NIDDK · UNIVERSITY OF IOWA · PI KREDER, KARL J · 2008 to 2021
$9.8M
University of Michigan MAPP Research Network Discovery SiteU01DK082345 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CLAUW, DANIEL J, CLEMENS, J. QUENTIN · 2008 to 2021
$9.7M
Neurobiological endophenotypes & gene-environment interactions in IC/PBS & in aU01DK082370 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUTCH, JASON J., MAYER, EMERAN A · 2008 to 2021
$9.2M
WSU Urologic Chronic Pelvic Pain Syndromes Discovery CenterU01DK082325 · NIDDK · WASHINGTON STATE UNIVERSITY · PI BOGIC, MARIJA · 2008 to 2021
$9.0M
Washington University MAPP Network Discovery SiteU01DK082315 · NIDDK · WASHINGTON UNIVERSITY · PI LAI, HING HUNG HENRY · 2008 to 2021
$9.0M
MAPP Research Network Tissue Analysis and Technology CoreU01DK082333 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LUCIA, M. SCOTT · 2008 to 2018
$6.1M
Limited Competition for Continuation of the MAPP-RN DCCU24DK082316 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI LANDIS, J RICHARD · 2019 to 2021
$4.9M
Expansion of the MAPP Research Network: Microbial and Biopsychosocial ContributioU01DK103271 · NIDDK · QUEEN'S UNIVERSITY AT KINGSTON · PI NICKEL, JOHN CURTIS · 2014 to 2018
$1.2M
Discovery, Validation and Clinical Application of Novel, Non-Invasive BiomarkersU01DK103227 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI LEE, RICHARD SANG-YONG, MOSES, MARSHA A · 2014 to 2018
$1.2M
Microbiome and Proteome As Predictive Biomarkers of UCPPSU01DK103260 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI ANGER, JENNIFER TASH, FREEMAN, MICHAEL R · 2014 to 2018
$1.2M
NIDDK NIH HHS U01 DK082315NIDDK NIH HHS U01 DK082316NIDDK NIH HHS U01 DK082325NIDDK NIH HHS U01 DK082333NIDDK NIH HHS U01 DK082342NIDDK NIH HHS U01 DK082344NIDDK NIH HHS U01 DK082345NIDDK NIH HHS U01 DK082370NIDDK NIH HHS U01 DK103227NIDDK NIH HHS U01 DK103260NIDDK NIH HHS U01 DK103271NIDDK NIH HHS U24 DK082316NIDDK NIH HHS U24 DK082333This research was supported by the National Institute of Diabetes and Digestive and Kidney Diseases.
6 · The paper itself

Abstract

objectiveTo assess differences in clinical presentation and illness impact in men and women presenting with urologic chronic pelvic pain syndrome (UCPPS) and between men diagnosed with interstitial cystitis/bladder pain syndrome (IC/BPS) or chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).

methods356 men and 605 women from six sites across the United States were assessed using a comprehensive set of demographic, symptom, and illness impact measures. Multivariable regression analyses examined differences between men and women and between men previously diagnosed with CP/CPPS or IC/BPS. In a stepwise manner, analyses tested group differences, controlling for demographic variables including symptom duration and presence of bladder pain that varied with filling and voiding.

resultsMen diagnosed with IC/BPS had the most severe UCPPS symptoms, followed by women with IC/BPS, and then men with CP/CPPS only. While men and women showed similar patterns of symptoms across most of the variables, women had increased widespread non-pelvic pain, greater pelvic floor tenderness on exam, and higher self-reported sensory sensitivity compared to men. About 60% of men diagnosed with CP/CPPS only reported bladder symptoms of painful filling or relief with voiding.

conclusionsA generally shared symptom pattern was found across men and women irrespective of diagnostic labels suggesting the use of key marker symptoms, such as severity of bladder symptoms and widespread pain, to better identify subgroups of UCPPS rather than diagnostic category. Women may have an increased likelihood of increased sensitivity and central sensitization than men, including those men with IC/BPS.

trial registrationClinicalTrials.gov Identifier: NCT02514265 - MAPP Research Network: Trans-MAPP Study of Urologic Chronic Pelvic Pain: Symptom Patterns Study (SPS).

Indexed as

Chronic PainCystitis, InterstitialPelvic PainProstatitisAdultAgedFemaleHumansMaleMiddle AgedPain MeasurementSex FactorsUnited Stateschronic prostatitisinterstitial cystitispainsex differencesurinary symptomsurologic chronic pelvic pain syndrome

Identifiers

PMID39704257
PMCPMC11788956

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.