Evidence map›Paper›PMID 39704243›Full record

ArticleJournal of the American Heart Association2025

Changes in Blood Eosinophil Counts Predict the Death of Patients With Myocardial Infarction After Hospital Discharge.

Kaiyang Lin, Manqing Luo, Xia Gu, Jun-Yan Xu, Jinwei Tian, Peter Libby, Guo-Ping Shi, Junli Guo

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kaiyang LinDepartment of Cardiology Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fujian Provincial Key Laboratory of Cardiovascular Disease Fuzhou China.
Manqing LuoDepartment of Cardiology Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fujian Provincial Key Laboratory of Cardiovascular Disease Fuzhou China.ORCID 0000-0002-5706-1432
Xia GuDepartment of Cardiology The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang China.ORCID 0000-0001-8030-3631
Jun-Yan XuGuangdong Provincial Key Laboratory of Coronary Heart Disease Prevention Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Guangzhou China.ORCID 0000-0001-7772-0469
Jinwei TianDepartment of Cardiology The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang China.ORCID 0000-0002-2730-0033
Peter LibbyDepartment of Medicine Brigham and Women's Hospital, and Harvard Medical School Boston MA USA.ORCID 0000-0002-1502-502X
Guo-Ping ShiDepartment of Medicine Brigham and Women's Hospital, and Harvard Medical School Boston MA USA.ORCID 0000-0001-5809-2567
Junli GuoKey Laboratory of Tropical Translational Medicine of Ministry of Education & Key Laboratory of Tropical Cardiovascular Diseases Research of Hainan Province, School of Public Health Hainan Medical University Haikou China.ORCID 0000-0002-9740-9819

Funding

Role of Mast cells in Alzheimer's DiseaseR01AG063839 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 2020 to 2024
$3.1M
Role of group 2 innate lymphoid cells in myocardial infarctionR01HL157073 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 2022 to 2025
$2.7M
Role of ILC2 and eosinophils in abdominal aortic aneurysmR01HL151627 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 2021 to 2024
$2.7M
Mechanisms and Modulation of Accelerated Atherosclerosis in Clonal HematopoiesisR01HL163099 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 2022 to 2025
$2.6M
Role of eosinophil cationic proteins in cardiac hypertrophyR01HL166538 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 2023 to 2025
$2.1M
Role of CLCA1 as a MIF decoy inhibitor in abdominal aortic aneurysmsR01HL170000 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter Libby · 2024 to 2026
$2.1M
Novel mechanisms of the thrombotic complications of atherosclerosisR01HL134892 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 2019 to 2022
$1.7M
NHLBI NIH HHS R01 HL134892NHLBI NIH HHS R01 HL151627NHLBI NIH HHS R01 HL157073NHLBI NIH HHS R01 HL163099NHLBI NIH HHS R01 HL166538NHLBI NIH HHS R01 HL170000NIA NIH HHS R01 AG063839
6 · The paper itself

Abstract

backgroundPreclinical studies demonstrate a cardioprotective role of eosinophils in acute myocardial infarction. Yet clinical studies show conflicting correlations between blood eosinophil counts and acute myocardial infarction risk and mortality. This study evaluates blood eosinophil counts of patients with acute myocardial infarction at hospital admission (EOS METHODS AND

resultsOf 2681 consecutive patients with a median follow-up of 2.55 years, 45 patients died within 30 days, 28 died within 30 to 150 days, and 92 died within 150 days or later postdischarge. Cardiac death occurred in 108 patients. According to the receiver operating characteristic analyses, the best cutoffs of EOS

conclusionsHigh and low blood eosinophil counts both predict the risk of all-cause and cardiac deaths in patients with acute myocardial infarction depending on the time of data collection. Dynamic changes of blood eosinophil counts offer a more accurate prediction of post-myocardial infarction deaths than a single time point data analysis.

Indexed as

EosinophilsMyocardial InfarctionPatient DischargeAgedCause of DeathFemaleHumansLeukocyte CountMaleMiddle AgedPredictive Value of TestsPrognosisRetrospective StudiesRisk AssessmentRisk FactorsROC Curveacute myocardial infarctionall‐cause mortalitycardiac deatheosinophilhospital discharge

Identifiers

PMID39704243
PMCPMC12054474

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.