Evidence map›Paper›PMID 39704229›Full record

ArticleJournal of the American Heart Association2025

Multilevel Mediators on the Associations of Neighborhood Social Environmental Factors and Severity of Metabolic Syndrome: The Jackson Heart Study.

Mohammad Moniruzzaman, Lauren A Reid, Kelly K Jones, Shannon N Zenk, Gloria L Vega, Scott M Grundy, Mario Sims, Tiffany M Powell-Wiley, Kosuke Tamura

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mohammad MoniruzzamanSocio-Spatial Determinants of Health (SSDH) Laboratory, Population and Community Health Sciences Branch, Division of Intramural Research, National Institute on Minority Health and Health Disparities National Institutes of Health Bethesda MD.ORCID 0000-0003-2144-7111
Lauren A ReidSouth College, School of Physician Assistant Studies Atlanta GA.ORCID 0000-0003-1021-8364
Kelly K JonesNeighborhoods and Health Laboratory, Population and Community Health Sciences Branch, Division of Intramural Research, National Institute on Minority Health and Health Disparities National Institutes of Health Bethesda MD.ORCID 0000-0002-1552-7847
Shannon N ZenkNeighborhoods and Health Laboratory, Population and Community Health Sciences Branch, Division of Intramural Research, National Institute on Minority Health and Health Disparities National Institutes of Health Bethesda MD.ORCID 0000-0003-2409-7022
Gloria L VegaCenter for Human Nutrition University of Texas Southwestern Medical Center Dallas TX.
Scott M GrundyCenter for Human Nutrition University of Texas Southwestern Medical Center Dallas TX.
Mario SimsDepartment of Social Medicine, Population and Public Health, University of California Riverside School of Medicine University of California Riverside CA.ORCID 0009-0006-4083-8328
Tiffany M Powell-WileySocial Determinants of Obesity and Cardiovascular Risk Laboratory, Cardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute National Institutes of Health Bethesda MD.ORCID 0000-0001-9488-4131
Kosuke TamuraSocio-Spatial Determinants of Health (SSDH) Laboratory, Population and Community Health Sciences Branch, Division of Intramural Research, National Institute on Minority Health and Health Disparities National Institutes of Health Bethesda MD.ORCID 0000-0002-4920-2856

Funding

Tailoring Mobile Health Technology to Reduce Obesity and ImproveCardiovascular Health in Resource-Limited Neighborhood Environments: A Multi-Level, Community-Based Physical Activity InterventionZIAHL006225 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI POWELL-WILEY, TIFFANY · 2017 to 2025
$9.7M
Cardiovascular Health and Needs Assessment in Washington D.C.ZIAHL006168 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI POWELL-WILEY, TIFFANY · 2013 to 2025
$8.1M
UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeffrey M Zigman · 2022 to 2026
$7.4M
Pilot Study for Geospatial Analysis of Neighborhood Environmental Stress in Relation to Biological Markers of Cardiovascular Health and Health Behaviors in WomenZIAHL006252 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI POWELL-WILEY, TIFFANY · 2020 to 2025
$5.7M
NIMHD Adjunct Investigator ProgramZIJMD000010 · NIMHD · NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES · PI CHOI, KELVIN · 2017 to 2025
$3.4M
Socio-Spatial Determinants of Health (SSDH) ZIAMD000020 · NIMHD · NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES · PI TAMURA, KOSUKE · 2021 to 2025
$1.0M
Intramural NIH HHS ZIA HL006168Intramural NIH HHS ZIA HL006225Intramural NIH HHS ZIA HL006252Intramural NIH HHS ZIA MD000020Intramural NIH HHS ZIJ MD000010NIDDK NIH HHS P30 DK127984
6 · The paper itself

Abstract

backgroundNeighborhood characteristics serve as risk factors for metabolic syndrome (MetS). However, the intermediary factors linking this relationship remain understudied. Thus, we investigated the sex-specific mediating role of C-reactive protein, physical activity (PA), and perceived stress in the associations of perceived neighborhood social environment (PNSE) with MetS severity among Black adults. METHODS AND

resultsThis cross-sectional study included 3185 adults (64% women) from exam 1 (2000-2004) of the Jackson Heart Study. MetS severity

conclusionsAll PNSEs (violence, problems, and social cohesion) were directly related to MetS severity in women only. PA mediated the relationship between each PNSE and MetS in a sex-specific manner. Efforts focusing on local conditions are needed to better understand why such disparities exist for at-risk minoritized groups.

Indexed as

Black or African AmericanC-Reactive ProteinMetabolic SyndromeSeverity of Illness IndexSocial EnvironmentAdultAgedCross-Sectional StudiesExerciseFemaleHumansMaleMiddle AgedMississippiNeighborhood CharacteristicsResidence CharacteristicsC-Reactive ProteinC‐reactive proteinmediation analysismetabolic syndromeneighborhoodphysical activity

Identifiers

PMID39704229
PMCPMC12054426

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.