Evidence map›Paper›PMID 39704041›Full record

ArticleOncoimmunology2025

Assessment of adenosinergic activity of small extracellular vesicles in plasma of cancer patients and healthy donors.

Chang Sook Hong, Elizabeth V Menchikova, Yana Najjar, Theresa L Whiteside, Edwin K Jackson

Abstract read
In one paragraph

Article in Oncoimmunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chang Sook HongDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Elizabeth V MenchikovaDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Yana NajjarCancer Research, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Theresa L WhitesideDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0001-7316-6181
Edwin K JacksonDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Funding

The Adenosinergic Pathway in Tumor-derived ExosomesR01CA256068 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JACKSON, EDWIN KERRY, WHITESIDE, THERESA L. · 2021 to 2025
$2.5M
NCI NIH HHS R01 CA256068
6 · The paper itself

Abstract

The adenosinergic pathway converting endogenous ATP to adenosine (ADO) is a major immunosuppressive pathway in cancer. Emerging data indicate that plasma small extracellular vesicles (sEV) express CD39 and CD73 and produce ADO. Using a noninvasive, highly sensitive newly developed assay, metabolism of N

Indexed as

5'-NucleotidaseAdenosineApyraseExtracellular VesiclesAdenosine DiphosphateAdultAgedAntigens, CDCase-Control StudiesFemaleGPI-Linked ProteinsHumansMaleMelanomaMiddle AgedNeoplasms5'-NucleotidaseAdenosineAdenosine DiphosphateAntigens, CDApyraseENTPD1 protein, humanGPI-Linked ProteinsNT5E protein, humanCancerecto-nucleotidase metabolismN6-etheno-purine assayTEXtumor-derived extracellular vesicles

Identifiers

PMID39704041
PMCPMC12952743

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.