ArticleEuropean journal of orthodontics2024
Relative contributions of genetic and environmental factors to palatal morphology: a longitudinal twin study.
Article in European journal of orthodontics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed.
- Three-Dimensional Variation of the Human Hard Palate Across Populations: A Geometric Morphometrics Study.Dentistry journal · 2026Article
- Development of a Deep Learning Model to Automatically Identify Palatal Landmarks on Three-Dimensional Maxillary Dental Casts.International journal of dentistry · 2026Article
- Digital Twins for Personalized Medicine Require Epidemiological Data and Mathematical Modeling: Viewpoint.Journal of medical Internet research · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
objectivesThis study aimed to determine the genetic and environmental contributions to phenotypic variations of palatal morphology during development.
methodsLongitudinal three-dimensional digital maxillary dental casts of 228 twin pairs (104 monozygotic and 124 dizygotic) at primary, mixed, and permanent dentition stages were included in this study. Landmarks were placed on the casts along the midpoints of the dento-gingival junction on the palatal side of each tooth and the mid-palatine raphe using MeshLab. Palatal widths, depths, length, area, and volume were measured using those landmarks. Univariate genetic structural equation modelling was performed on twin data at each stage of dental development.
resultsExcept for anterior depth, all palatal dimensions increased significantly from the primary to permanent dentition stages. The phenotypic variance for most of the palatal dimensions during development was best explained by a model, including additive genetic and non-shared environment variance components. Variance in volume and area in the primary dentition stage was best explained by a model including additive genetic, shared environment, and non-shared environment variance components. For posterior palatal depth and width, narrow-sense heritability estimates were above 0.8 for all dental developmental stages. In contrast, heritability estimates for other palatal traits fluctuated during development. LIMITATION: This study was limited to twins of European ancestry.
conclusionsAdditive genetic and non-shared environmental factors primarily influenced palatal morphology during development. While the genetic influence on different aspects of the palate varied throughout development, it was particularly strong in the posterior region of the palate and during the permanent dentition stage.
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