Evidence map›Paper›PMID 39703930›Full record

ArticlePlant direct2024

Synthesis of β-Alanine From Isoleucine and Propionate Catabolism via Aminotransferases.

Margo H Goldfarb, Joseph Boesel, Kai C Wilczewski-Shirai, Peter Reinhart, Trenton Scherger, Chloe Webb, Morgan Newlun, Kerry A Rouhier

Abstract read
In one paragraph

Article in Plant direct, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Margo H GoldfarbDepartment of Chemistry Kenyon College Gambier Ohio USA.
Joseph BoeselDepartment of Chemistry Kenyon College Gambier Ohio USA.ORCID https://orcid.org/0009-0005-2849-5820
Kai C Wilczewski-ShiraiDepartment of Chemistry Kenyon College Gambier Ohio USA.
Peter ReinhartDepartment of Chemistry Kenyon College Gambier Ohio USA.
Trenton SchergerDepartment of Chemistry Kenyon College Gambier Ohio USA.
Chloe WebbDepartment of Chemistry Kenyon College Gambier Ohio USA.
Morgan NewlunDepartment of Chemistry Kenyon College Gambier Ohio USA.
Kerry A RouhierDepartment of Chemistry Kenyon College Gambier Ohio USA.ORCID https://orcid.org/0009-0005-2617-7159

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In plants, the nonproteinogenic amino acid β-alanine plays a role in response to hypoxia, flooding, drought, heat, and heavy metal stress conditions. It is also a key intermediate in the synthesis of essential molecules including vitamin B5 and coenzyme A (CoA) through the condensation reaction with pantoate. While the syntheses of pantoate, vitamin B5, and CoA appear to be conserved across plants and bacteria, the synthesis of β-alanine is not. Bacteria and fungi use aspartate, whereas plants can use uracil, spermidine, or propionate to synthesize β-alanine. Given that these three precursors can be formed from the metabolism of glutamine, arginine, isoleucine, and valine, the synthesis of β-alanine could be linked to numerous pathways. Studies of valine catabolism in

Indexed as

aminotransferasearabidopsispropionate (or propionyl‐CoA)β‐Alanine

Identifiers

PMID39703930
PMCPMC11655180

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.