Evidence map›Paper›PMID 39703814›Full record

ArticleRegenerative therapy2025

Modeling vascular dynamics at the initial stage of endochondral ossification on a microfluidic chip using a human embryonic-stem-cell-derived organoid.

Abhiraj Kesharwani, Shoichiro Tani, Masaki Nishikawa, Yasuyuki Sakai, Hiroyuki Okada, Shinsuke Ohba, Ung-Il Chung, Hironori Hojo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Abhiraj KesharwaniDepartment of Bioengineering, Graduate School of Engineering, The University of Tokyo, Tokyo 113-8654, Japan.
Shoichiro TaniCenter for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Masaki NishikawaDepartment of Chemical Systems Engineering, Graduate School of Engineering, The University of Tokyo, Tokyo 113-8654, Japan.
Yasuyuki SakaiDepartment of Chemical Systems Engineering, Graduate School of Engineering, The University of Tokyo, Tokyo 113-8654, Japan.
Hiroyuki OkadaCenter for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Shinsuke OhbaDepartment of Tissue and Developmental Biology, Graduate School of Dentistry, Osaka University, Osaka 565-0871, Japan.
Ung-Il ChungDepartment of Bioengineering, Graduate School of Engineering, The University of Tokyo, Tokyo 113-8654, Japan.
Hironori HojoDepartment of Bioengineering, Graduate School of Engineering, The University of Tokyo, Tokyo 113-8654, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vascular interactions play a crucial role in embryogenesis, including skeletal development. During endochondral ossification, vascular networks are formed as mesenchymal cells condense and later invade skeletal elements to form the bone marrow. We and other groups developed a model of endochondral ossification by implanting human embryonic stem cell (hESC)-derived sclerotome into immunodeficient mice. However,

Indexed as

Endochondral ossificationHuman embryonic stem cellsMicrofluidic platformOrganoid-on-a-chipSclerotome cellsVascular interaction

Identifiers

PMID39703814
PMCPMC11655692

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.