ArticleBiochemia medica2025
Levothyroxine therapy reduces endocan and total cholesterol concentrations in patients with subclinical hypothyroidism.
Article in Biochemia medica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Cardiometabolic Outcomes and Levothyroxine Treatment Effects in Subclinical Hypothyroidism: A Systematic Review.Cureus · 2026Review
- Assessment of biomarkers of thyroid hormone action across three thyroid hormone replacement regimens in hypothyroidism.Frontiers in endocrinology · 2026Article
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Authors and funding
8 authors.
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Abstract
Introduction: Subclinical hypothyroidism (SCH) is an independent risk factor for cardiovascular diseases due to endothelial dysfunction and atherosclerosis development. The aim of this study was to determine whether the levothyroxine therapy could impact the concentrations of endothelial dysfunction blood markers, namely endothelin-1 (ET-1), asymmetric dimethylarginine (ADMA) and endocan, in patients with a mild form of SCH (thyroid-stimulating hormone (TSH) ≤ 10 mIU/L). Materials and methods: In this case-control prospective study, SCH patients and healthy controls were recruited during their regular health examinations. Medical specialists prescribed levothyroxine to SCH patients if necessary. The endothelial dysfunction markers, as well as other biochemical markers, were measured in all subjects at baseline, and after 6 months of levothyroxine treatment following the euthyroidism. Results: Our study showed higher ADMA (248.00 (168.78-540.20) Conclusions: A mild form of SCH is associated with higher concentrations of endocan, ADMA, LDL and non-HDL. The potential benefits of levothyroxine therapy were shown through the significant decrease of endocan and CHOL concentrations in SCH patients, thus contributing the atherosclerosis prevention.
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