Evidence map›Paper›PMID 39703686›Full record

ArticleNEJM AI2024

Large Language Models for More Efficient Reporting of Hospital Quality Measures.

Aaron Boussina, Rishivardhan Krishnamoorthy, Kimberly Quintero, Shreyansh Joshi, Gabriel Wardi, Hayden Pour, Nicholas Hilbert, Atul Malhotra, Michael Hogarth, Amy M Sitapati and 4 more

Registry-linked trialAbstract read
In one paragraph

Article in NEJM AI, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07581340 (Impact of Automated Sepsis Metric Evaluation on Provider Performance), which is not on this map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07581340 nacompletednot on this map

Impact of Automated Sepsis Metric Evaluation on Provider Performance

TypeinterventionalSponsorUniversity of California, San DiegoRan2024 to 2025Enrolled66ConditionsSepsisArmsNear-real time automated feedback on SEP-1 performance
3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Aaron BoussinaDivision of Biomedical Informatics, University of California, San Diego, San Diego.ORCID 0000-0003-0944-5906
Rishivardhan KrishnamoorthyDivision of Biomedical Informatics, University of California, San Diego, San Diego.ORCID 0009-0009-6840-999X
Kimberly QuinteroDepartment of Quality, University of California, San Diego, San Diego.ORCID 0009-0001-7711-0713
Shreyansh JoshiDivision of Biomedical Informatics, University of California, San Diego, San Diego.ORCID 0000-0003-3496-4732
Gabriel WardiDivision of Biomedical Informatics, University of California, San Diego, San Diego.ORCID 0000-0002-4845-0217
Hayden PourDivision of Biomedical Informatics, University of California, San Diego, San Diego.ORCID 0009-0004-3374-6471
Nicholas HilbertDepartment of Quality, University of California, San Diego, San Diego.ORCID 0009-0003-2098-5265
Atul MalhotraDepartment of Medicine, University of California, San Diego, San Diego.ORCID 0000-0002-9509-1827
Michael HogarthDivision of Biomedical Informatics, University of California, San Diego, San Diego.ORCID 0000-0002-4264-1258
Amy M SitapatiDivision of Biomedical Informatics, University of California, San Diego, San Diego.ORCID 0000-0002-5737-5925
Chad VanDenBergDepartment of Quality, University of California, San Diego, San Diego.ORCID 0009-0009-2853-8754
Karandeep SinghJoan & Irwin Jacobs Center for Health Innovation, University of California, San Diego, San Diego.ORCID 0000-0001-8980-2330
Christopher A LonghurstDepartment of Medicine, University of California, San Diego, San Diego.ORCID 0000-0003-4908-6856
Shamim NematiDivision of Biomedical Informatics, University of California, San Diego, San Diego.ORCID 0000-0002-0520-4948

Funding

San Diego Biomedical Informatics Education & Research (SABER)T15LM011271 · NLM · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHAMIM NEMATI · 2012 to 2026
$9.7M
GeneRAlizable Sepsis Phenotyping (GRASP) using Electronic Health Records and Continuous Monitoring SensorsR35GM143121 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NEMATI, SHAMIM · 2021 to 2025
$2.2M
AIVIS: Next Generation Vigilant Information Seeking Artificial Intelligence-based Clinical Decision Support for SepsisR42AI177108 · NIAID · HEALCISIO, INC. · PI JOSEF, CHRISTOPHER · 2023 to 2024
$1.3M
Implementation of Continuum of Care Sepsis Phenotyping and Risk StratificationK23GM146092 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Gabriel Wardi · 2022 to 2026
$898k
NIAID NIH HHS R42 AI177108NIGMS NIH HHS K23 GM146092NIGMS NIH HHS R35 GM143121NLM NIH HHS T15 LM011271
6 · The paper itself

Abstract

Hospital quality measures are a vital component of a learning health system, yet they can be costly to report, statistically underpowered, and inconsistent due to poor interrater reliability. Large language models (LLMs) have recently demonstrated impressive performance on health care-related tasks and offer a promising way to provide accurate abstraction of complete charts at scale. To evaluate this approach, we deployed an LLM-based system that ingests Fast Healthcare Interoperability Resources data and outputs a completed Severe Sepsis and Septic Shock Management Bundle (SEP-1) abstraction. We tested the system on a sample of 100 manual SEP-1 abstractions that University of California San Diego Health reported to the Centers for Medicare & Medicaid Services in 2022. The LLM system achieved agreement with manual abstractors on the measure category assignment in 90 of the abstractions (90%; κ=0.82; 95% confidence interval, 0.71 to 0.92). Expert review of the 10 discordant cases identified four that were mistakes introduced by manual abstraction. This pilot study suggests that LLMs using interoperable electronic health record data may perform accurate abstractions for complex quality measures. (Funded by the National Institute of Allergy and Infectious Diseases [1R42AI177108-1] and others.).

Identifiers

PMID39703686
PMCPMC11658346

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.