Adipose Tissue, Regeneration, and Skin Health: The Next Regenerative Frontier.

Adipose tissue, or fat compartments, has long been considered a storage depot and an energy source. However, a large part of new research, starting with the discovery of adipose-derived stem cells, has redirected this thinking toward the tremendous regenerative capacity that adipose tissue possesses when it is healthy. This has resulted in multiple technologies being explored with fat as a basis or with fat as a target aiming at the stimulation of new small hyperplastic adipose cells exuding adipokines and encouraging the proliferation of a whole host of progenitor cells that can have positive effects on many organ systems. One of these organ systems is skin, and there is a direct correlation with various fat compartments and skin health. Dermal fat tissue, also known as dermal white adipose tissue, is one such compartment that originates from dermal preadipocytes transdifferentiating into adipocytes and progenitor adipose cells under the right cues. The author of this paper discusses these potential cues, including injectable fillers, fat grafts, and topical formulations, and their capacity to impact skin health through the generation of healthy fat tissue. In addition, small molecules such as glucagon-like peptide-1 peptides and their impact on fat tissue are discussed. Adipose tissue is being recognized as the next regenerative frontier with exciting prospects ahead. Level of Evidence 5 Therapeutic: