Evidence map›Paper›PMID 39703341›Full record

ArticleToxicology research2024

Protective effects of quercetin against tongue injury and oxidative stress triggered by irinotecan: a histopathological, biochemical and molecular study.

Eman Mohamed Faruk, Fatma Ibrahim, Mahmoud M Hassan, Kamal M Kamal, Dina Allam Abdelmaksoud Hassan, Ayat Abu-Elnasr Awwad, Neama Mahmoud Taha, Mohamed Ghazy Attia Hablas, Ahmed Mohammed Zaazaa, Mai Hassan Ibrahim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eman Mohamed FarukAnatomy Department, College of Medicine, Umm Al-Qura University, Al Abidiyah, Makkah, Saudi Arabia.ORCID https://orcid.org/0000-0002-8093-2769
Fatma IbrahimDepartment of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Zagazig University, Zagazig Rd inside Zagazig University, Shaibet an Nakareyah, Zagazig 44519, Al-Sharqia Governorate,Egypt.ORCID https://orcid.org/0000-0003-0011-9389
Mahmoud M HassanDepartment of Physiology, Faculty of Medicine, Benha University, Al Nadi Al Ryadi, Qism Benha, Al-Qalyubia Governorate, Benha 13518, Benha, Egypt.ORCID https://orcid.org/0009-0006-1551-2035
Kamal M KamalDepartment of Anatomy and Embryology, Faculty of Medicine, Benha University, Al Nadi Al Ryadi, Qism Benha, Al-Qalyubia Governorate, Benha 13518, Benha, Egypt.ORCID https://orcid.org/0009-0007-2990-3288
Dina Allam Abdelmaksoud HassanDepartment of Histology and Cell Biology, Faculty of medicine for girls, Al-Azhar University, Cairo 11651, Cairo, Egypt.ORCID https://orcid.org/0000-0003-2677-9318
Ayat Abu-Elnasr AwwadDepartment of Otorhinolaryngology, Faculty of Medicine, Al-Azhar University, Cairo 11751, Cairo, Egypt.ORCID https://orcid.org/0000-0001-5815-051X
Neama Mahmoud TahaDepartment of Physiology, Umm Al-Qura University, Al Abidiyah, Makkah, Saudi Arabia.ORCID https://orcid.org/0009-0003-1402-2251
Mohamed Ghazy Attia HablasDepartment of Histology and Cell biology, faculty of medicine, Suez University, Suez 43221, Suez, Egypt.ORCID https://orcid.org/0009-0005-9264-7470
Ahmed Mohammed ZaazaaStudent at Faculty of Medicine, Benha National University, Benha Colleges in Cairo, Main Axis of El-Obour City, Egypt.ORCID https://orcid.org/0009-0008-4853-952X
Mai Hassan IbrahimDepartment of Anatomy and Embryology, Faculty of Medicine, Benha University, Al Nadi Al Ryadi, Qism Benha, Al-Qalyubia Governorate, Benha 13518, Benha, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: About 80% of patients receiving chemotherapeutics suffer from side effects related to the gastrointestinal tract. Irinotecan (CPT-11) is a chemotherapeutic agent usually used in treating solid tumors. Quercetin (QRT), a bioflavonoid, is an antioxidant and scavenger reactive oxygen species scavenger. Objective: The current study explored the possible protective effects of QRT against mucosal tongue injury caused by CPT-11. Methods: The study included four equal groups: group 1/control, group 2/QRT, group 3/CPT-11, and group 4/CPT-11 + QRT. Results: CPT-11-induced tongue injury in the form of non-healed ulcers, absent lingual papillae, mononuclear cells infiltration, marked deposition of collagen fibers, and overexpression of CD86 and tumor necrosis factor- α (TNF-α). The increased malondialdehyde levels, decreased superoxide dismutase and total antioxidant capacity revealed that there was an oxidative stress. Also, there was a decreased countenance of Ki-67 and Bcl-2 and an increased countenance of NF-κB. The QRT-treated group showed complete ulcer healing, with histological features almost like the control group, along with minimal collagen fiber deposition, decreased reactivity to CD86 and TNF-α and improvement of oxidative stress status and the molecular study results as well. Conclusion: QRT possess protective properties against CPT-11-triggered tongue injury.

Indexed as

CD86CPT-11FlavonoidsMalondialdehydeOxidative stress

Identifiers

PMID39703341
PMCPMC11652611

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.