Evidence map›Paper›PMID 39703237›Full record

ArticleClinical case reports2024

Implementation of Dialyzable Leukocyte Extract to Treat Multiple Sclerosis: A Clinical Case.

Layla Grecia González-González, Vicente Panameño-Cruz, Juan Pedro Luna-Arias, Elizabeth Reyna-Beltrán

Abstract read
In one paragraph

Article in Clinical case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Layla Grecia González-GonzálezFaculty of Medicine "Dr. Alberto Romo Caballero" Autonomous University of Tamaulipas Tampico Mexico.ORCID https://orcid.org/0009-0006-8855-0374
Vicente Panameño-CruzFaculty of Medicine "Dr. Alberto Romo Caballero" Autonomous University of Tamaulipas Tampico Mexico.ORCID https://orcid.org/0009-0005-8763-1482
Juan Pedro Luna-AriasDepartment of Cell Biology Center for Research and Advanced Studies of the National Polytechnic Institute (Cinvestav-IPN) Mexico City Mexico.ORCID https://orcid.org/0000-0002-3602-8000
Elizabeth Reyna-BeltránFaculty of Medicine "Dr. Alberto Romo Caballero" Autonomous University of Tamaulipas Tampico Mexico.ORCID https://orcid.org/0000-0001-7896-0560

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS) is an autoimmune demyelinating disease that affects the central nervous system (CNS) with its chronic inflammatory component. In the treatment of MS, corticosteroids are usually implemented to reduce the disease's inflammation rate. In this case study, we present a patient with MS that initially received corticosteroids, which heightened his vulnerability to infections, particularly respiratory ones. Consequently, the treatment was changed to the administration of dialyzable leukocyte extract (DLE) "Oral Transferon". To this day, the rate of inflammation has been reduced, slowing the evolution of MS, decreasing the clinical manifestations of the disease, and improving the patient's quality of life. This may be attributed to the immunomodulatory effects of the Transferon. More studies are needed in MS patients implementing a treatment based solely on Transferon to establish its effectiveness as an immunomodulator (specifically for this autoimmune disease).

Indexed as

autoimmune diseasedemyelinating plaqueimmunomodulationmultiple sclerosisoral Transferon

Identifiers

PMID39703237
PMCPMC11655175

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.