Evidence map›Paper›PMID 39703140›Full record

ArticleCell proliferation2025

Comparative Analysis of the Therapeutic Potential of Extracellular Vesicles Secreted by Aged and Young Bone Marrow-Derived Mesenchymal Stem Cells in Osteoarthritis Pathogenesis.

Shital Wakale, Yang Chen, Antonia Rujia Sun, Chamikara Liyanage, Jennifer Gunter, Jyotsna Batra, Ross Crawford, Hongxun Sang, Indira Prasadam

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell proliferation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shital WakaleCentre for Biomedical Technologies, Queensland University of Technology, Brisbane, Australia.
Yang ChenDepartment of Orthopaedics, Shenzhen Hospital of Southern Medical University, Shenzhen, China.
Antonia Rujia SunCentre for Biomedical Technologies, Queensland University of Technology, Brisbane, Australia.
Chamikara LiyanageCancer Single Cell Genomics Laboratory, Translational Breast Cancer Program, Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia.
Jennifer GunterAustralian Prostate Cancer Research Centre-Queensland, Centre for Genomics and Personalised Health, School of Biomedical Science, Queensland University of Technology, Translational Research Institute, Brisbane, Queensland, Australia.
Jyotsna BatraAustralian Prostate Cancer Research Centre-Queensland, Centre for Genomics and Personalised Health, School of Biomedical Science, Queensland University of Technology, Translational Research Institute, Brisbane, Queensland, Australia.
Ross CrawfordCentre for Biomedical Technologies, Queensland University of Technology, Brisbane, Australia.
Hongxun SangDepartment of Orthopaedics, Shenzhen Hospital of Southern Medical University, Shenzhen, China.
Indira PrasadamCentre for Biomedical Technologies, Queensland University of Technology, Brisbane, Australia.ORCID https://orcid.org/0000-0001-5057-2427

Funding

NHMRC Investigator grant fellowship APP1176298Shenzhen Development and Reform Program XMHT20220106001Shenzhen Fundamental Research Key Project JCYJ20200109150641992Shenzhen Key Laboratory of Digital Surgical Printing Project ZDSYS201707311542415Shenzhen Science and Technology Innovation Committee JCYJ20170818164059405Shenzhen Science and Technology Program JCYJ20220818103417037,SGDX20201103095600002
6 · The paper itself

Abstract

Osteoarthritis (OA), a joint disease, burdens global healthcare due to aging and obesity. Recent studies show that extracellular vesicles (EVs) from bone marrow-derived mesenchymal stem cells (BMSCs) contribute to joint homeostasis and OA management. However, the impact of donor age on BMSC-derived EV efficacy remains underexplored. In this study, we investigated EV efficacy from young BMSCs (2-month-old) in mitigating OA, contrasting them with EVs from aged BMSCs (27-month-old). The study used destabilisation of the medial meniscus (DMM) surgery on mouse knee joints to induce accelerated OA. Cartilage degeneration markers and senescence markers' expression levels were investigated in response to EV treatment. The therapeutic impact of EVs on chondrocytes under inflammatory responses was also evaluated. Despite having similar morphologies, EVs from young BMSCs markedly decreased senescence and improved chondroprotection by activating the PTEN pathway while simultaneously suppressing the upregulation of the PI3K/AKT pathways, proving to be more effective than those from older BMSCs in vitro. Furthermore, intraperitoneal injections of EVs from young donors significantly mitigated OA progression by preserving cartilage and reducing synovitis in a surgical OA model using DMM in mice. These findings highlight that donor age as a critical determinant in the therapeutic potential of BMSC-derived EVs for clinical use in OA treatment.

Indexed as

Extracellular VesiclesMesenchymal Stem CellsOsteoarthritisAgingAnimalsBone Marrow CellsCells, CulturedCellular SenescenceChondrocytesDisease Models, AnimalMaleMesenchymal Stem Cell TransplantationMiceMice, Inbred C57BLageingbone marrow mesenchymal stem cellscartilageextracellular vesiclesosteoarthritissenescence

Identifiers

PMID39703140
PMCPMC11969246

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.